• Advances in Anion Receptor Chemistry 

      Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.
      Published 2020-01-01
      This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...
      Open Access
      Article
    • Advances in applied supramolecular technologies 

      Williams, George T.; Haynes, Cally J.E.; Fares, Mohamed; Caltagirone, Claudia; Hiscock, Jennifer; Gale, Philip A.
      Published 2021
      Supramolecular chemistry is a comparatively young field that to date has mainly been focused on building a foundation of fundamental understanding. With much progress in this area, researchers are seeking to apply this ...
      Open Access
      Article
    • Advances in fluorescent and colorimetric sensors for anionic species 

      McNaughton, Daniel A.; Fares, Mohamed; Picci, Giacomo; Gale, Philip A.; Caltagirone, Claudia
      Published 2021
      In this review we cover recent developments in fluorescent and colorimetric anion sensors. These systems employ a range of different non-covalent interactions including hydrogen- and halogen-bonding, Lewis acidic boron-based ...
      Open Access
      Preprint
    • Amino acid-based squaramides for anion recognition 

      Elmes, Robert B. P.; Jolliffe, Katrina A.
      Published 2015-01-01
      Eight receptors 1–8 comprising an L-lysine scaffold modified at N- and C-termini with aliphatic alkyl chains and N,N0-alkyl amides, respectively, and bearing squaramide moieties on the amino acid side chain were synthesised ...
      Open Access
      Article
    • Anion binding in metal-organic frameworks 

      Wu, Xin; Gale, Philip A.
      Published 2021
      Despite commonly being used as the host for gases, solvents and other neutral molecules, metal-organic frameworks (MOFs) have received recent attention as supramolecular anion binding hosts with a broad range of environmental ...
      Open Access
      Preprint
    • Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs† 

      Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.
      Published 2019-10-01
      Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...
      Open Access
      Article
    • Anion receptor chemistry: Highlights from 2016 

      Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J.
      Published 2018-02-01
      This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.
      Open Access
      Article
    • Anion Recognition By Cyclic Peptides 

      Elmes, Robert B. P.; Jolliffe, Katrina A.
      Published 2015-01-01
      Anion binding selectivity can often be controlled by judicious arrangement of recognition moieties around an anion of interest. Indeed, nature takes advantage of large peptides/proteins to provide highly efficient and ...
      Open Access
      Article
    • Anion Recognition Using a Simple Cyclic Peptide 

      Sergeant, Genevieve; Jolliffe, Katrina
      Published 2020
      The head-to-tail cyclic hexapeptide, [cyclo(Val-Thr)3], was found to bind to a range of anions in DMSO-d6 with higher affinity for tetrahedral oxo-anions than halides. 1H NMR spectroscopy indicated that anion binding results ...
      Embargoed
      Article
    • Anion transport and supramolecular medicinal chemistry 

      Gale, Philip A.; Davis, Jeffery T.; Quesada, Roberto
      Published 2017-01-01
      New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...
      Open Access
      Article
    • Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes 

      Dias, Christopher M.; Li, Hongyu; Valkenier, Hennie; Karagiannidis, Louise E.; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.
      Published 2017-12-01
      Ortho-Phenylene bis-ureas serve as anionophores in cells expressing halide-sensitive yellow fluorescent protein, as well as in synthetic vesicles. Activities can reach high levels, and are strongly dependent on the ...
      Open Access
      Article
    • Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter 

      Rawling, Tristan; MacDermott-Opeskin, Hugh; Roseblade, Ariane; Pazderka, Curtis; Clarke, Callum; Bourget, Kirsi; Wu, Xin; Lewis, William; Noble, Benjamin; Gale, Philip A.; O'Mara, Megan L.; Cranfield, Charles; Murray, Michael
      Published 2020
      Respiring mitochondria establish a proton gradient across the mitochondrial inner membrane (MIM) that is used to generate ATP. Protein-independent mitochondrial uncouplers collapse the proton gradient and disrupt ATP ...
      Open Access
      Article
    • Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids 

      Müllner, Markus; Yang, Kylie; Kaur, Amandeep; New, Elizabeth Joy
      Published 2018-06-08
      Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition ...
      Open Access
      Article
    • Boundary flow on end-grafted PEG brushes 

      Charrault, E.; Lee, T.; Easton, C.D.; Neto, Chiara
      Published 2015-12-18
      We investigated the boundary conditions for flow of a Newtonian liquid over soft interfaces by measuring hydrodynamic drainage forces with colloid probe atomic force microscopy in a viscous liquid. The investigated soft ...
      Open Access
      Article
    • Carborane functionalization of the aromatic network in chemically-synthesized graphene 

      Kahlert, Jan U.; Rawal, Aditya; Hook, James M.; Rendina, Louis M.; Choucair, Mohammad
      Published 2014-08-06
      The conjugated aromatic system of graphene was used to trap the reactive, boron-rich 1,2-carborane cluster. Functionalization of the graphene surface was confirmed by solid-state MAS 11B NMR spectroscopy and quantified by ...
      Open Access
      Article
    • Chain Collapse and Interfacial Slip of Polystyrene Films in Good/ Nonsolvent Vapor Mixtures 

      Al-Khayat, O.; Geraghty, K.; Shou, K.; Nelson, A.; Neto, Chiara
      Published 2016-02-08
      We investigated the dynamics and morphology of dewetting of metastable polystyrene films (thickness 75− 500 nm) cast on silicon substrates, upon exposure to vapors of a mixture of toluene, a good solvent, and ethanol, a ...
      Open Access
      Article
    • Control of nanoparticle formation using the constrained dewetting of polymer brushes 

      Lee, Thomas; Hendy, Shaun C.; Neto, Chiara
      Published 2015-01-14
      We have used coarse-grained molecular dynamics simulations to investigate the use of pinned micelles formed by the constrained dewetting of polymer brushes to act as a template for nanoparticle formation. The evaporation ...
      Open Access
      Article
    • Crystal structures and electronic properties in 3d transition metal doped SrRuO3 

      Ilyas, Qasim; Peter, Blanchard; Kevin, S Knight; Jimmy, Ting; Brendan, Kennedy
      Published 2019
      The synthesis of polycrystalline samples of B-site doped SrRu1−xMxO3 with x ≤ 0.2 by solid state methods is described for a number of dopants (M = Mg, Mn, Fe, Co, Ni, Cu, or Zn) and the structures of these established using ...
      Article
    • Cubanes in Medicinal Chemistry 

      Reekie, Tristan A.; Williams, Craig M.; Rendina, Louis M.; Kassiou, Michael
      Published 2019
      Cubane is a highly strained saturated hydrocarbon system that has historically been of interest in theoretical organic chemistry. More recently it has become a molecule of interest for biological applications due to its ...
      Open Access
      Article
    • Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate 

      Ariawan, A. Daryl; Webb, James E.A.; Howe, Ethan N.W.; Gale, Philip A.; Thordarson, Pall; Hunter, Luke
      Published 2017-02-01
      Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...
      Open Access
      Article