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Acridinone-based anion transporters
McNaughton, Daniel A.; Macreadie, Lauren K.; Gale, Philip A.Published 2021The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea ...Open AccessArticle -
Activating ATRP Initiators to Incorporate End-Group Modularity into Photo-RAFT Polymerization
Hakobyan, Karen; McErlean, Christopher S.P.; Muellner, MarkusPublished 2020Heterogeneous photocatalysis is increasingly used in reversible deactivation radical polymerization (RDRP). In this study, we found that alkyl bromide redox chemistry typically found in atom transfer radical polymerization ...Open AccessArticle -
Advances in Anion Receptor Chemistry
Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.Published 2020-01-01This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...Open AccessArticle -
Advances in applied supramolecular technologies
Williams, George T.; Haynes, Cally J.E.; Fares, Mohamed; Caltagirone, Claudia; Hiscock, Jennifer; Gale, Philip A.Published 2021Supramolecular chemistry is a comparatively young field that to date has mainly been focused on building a foundation of fundamental understanding. With much progress in this area, researchers are seeking to apply this ...Open AccessArticle -
Advances in fluorescent and colorimetric sensors for anionic species
McNaughton, Daniel A.; Fares, Mohamed; Picci, Giacomo; Gale, Philip A.; Caltagirone, ClaudiaPublished 2021In this review we cover recent developments in fluorescent and colorimetric anion sensors. These systems employ a range of different non-covalent interactions including hydrogen- and halogen-bonding, Lewis acidic boron-based ...Open AccessPreprint -
Alkali metal modified P2 NaxMnO2: Crystal structure and application in sodium-ion batteries
Sehrawat, D; Rawal, A; Cheong, S; Avdeev, Maxim; Ling, Chris D; Kimpton, J A; Sharma, NeerajPublished 2020Sodium-ion batteries (NIBs) are an emerging alternative to lithium-ion batteries because of abundant sodium re-sources and the potentially lower cost. Here we report the Na0.7MnO2 solid-state synthesized at 1000 oC which ...Open AccessArticle -
Amino acid-based squaramides for anion recognition
Elmes, Robert B. P.; Jolliffe, Katrina A.Published 2015-01-01Eight receptors 1–8 comprising an L-lysine scaffold modified at N- and C-termini with aliphatic alkyl chains and N,N0-alkyl amides, respectively, and bearing squaramide moieties on the amino acid side chain were synthesised ...Open AccessArticle -
Anion binding in metal-organic frameworks
Wu, Xin; Gale, Philip A.Published 2021Despite commonly being used as the host for gases, solvents and other neutral molecules, metal-organic frameworks (MOFs) have received recent attention as supramolecular anion binding hosts with a broad range of environmental ...Open AccessPreprint -
Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs†
Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.Published 2019-10-01Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...Open AccessArticle -
Anion receptor chemistry: Highlights from 2016
Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J.Published 2018-02-01This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.Open AccessArticle -
Anion Recognition By Cyclic Peptides
Elmes, Robert B. P.; Jolliffe, Katrina A.Published 2015-01-01Anion binding selectivity can often be controlled by judicious arrangement of recognition moieties around an anion of interest. Indeed, nature takes advantage of large peptides/proteins to provide highly efficient and ...Open AccessArticle -
Anion Recognition Using a Simple Cyclic Peptide
Sergeant, Genevieve; Jolliffe, KatrinaPublished 2020The head-to-tail cyclic hexapeptide, [cyclo(Val-Thr)3], was found to bind to a range of anions in DMSO-d6 with higher affinity for tetrahedral oxo-anions than halides. 1H NMR spectroscopy indicated that anion binding results ...Open AccessArticle -
Anion transport and supramolecular medicinal chemistry
Gale, Philip A.; Davis, Jeffery T.; Quesada, RobertoPublished 2017-01-01New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...Open AccessArticle -
Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes
Dias, Christopher M.; Li, Hongyu; Valkenier, Hennie; Karagiannidis, Louise E.; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.Published 2017-12-01Ortho-Phenylene bis-ureas serve as anionophores in cells expressing halide-sensitive yellow fluorescent protein, as well as in synthetic vesicles. Activities can reach high levels, and are strongly dependent on the ...Open AccessArticle -
Antifouling Properties of Liquid-Infused Riblets Fabricated by Direct Contactless Microfabrication
Fenati, Renzo A.; Quinn, Mitchell S.; Bilinksy, Henry C.; Neto, ChiaraPublished 2021The fabrication of riblets and surfaces structured with aligned grooves, by direct contactless microfabrication (DCM), and the ability of the riblets to function as lubricant-infused surfaces, is reported. Three types ...Open AccessArticle -
Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
Johansen-Leete, Jason; Ullrich, Sven; Fry, Sarah E.; Frkic, Rebecca; Bedding, Max J.; Aggarwal, Anupriya; Ashhurst, Anneliese S.; Ekanayake, Kasuni B.; Mahawaththa, Mithun C.; Sasi, Vishnu M.; Luedtke, Stephanie; Ford, Daniel J.; O'Donoghue, Anthony J.; Passioura, Toby; Larance, Mark; Otting, Gottfried; Turville, Stuart; Jackson, Colin J.; Nitsche, Christoph; Payne, Richard J.Published 2022Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (Mpro) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. Here we ...Article -
Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter
Rawling, Tristan; MacDermott-Opeskin, Hugh; Roseblade, Ariane; Pazderka, Curtis; Clarke, Callum; Bourget, Kirsi; Wu, Xin; Lewis, William; Noble, Benjamin; Gale, Philip A.; O'Mara, Megan L.; Cranfield, Charles; Murray, MichaelPublished 2020Respiring mitochondria establish a proton gradient across the mitochondrial inner membrane (MIM) that is used to generate ATP. Protein-independent mitochondrial uncouplers collapse the proton gradient and disrupt ATP ...Open AccessArticle -
Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids
Müllner, Markus; Yang, Kylie; Kaur, Amandeep; New, Elizabeth JoyPublished 2018-06-08Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition ...Open AccessArticle -
Binding and transport properties of a benzo[b]thiophene-based mono-(thio)urea library
Moiteiro, Cristina; Marques, Igor; Ryder, William G.; Cachatra, Vasco; Carvalho, Sílvia; Chen, Li-Jun; Goodfellow, Brian J.; Gale, Philip A.; Félix, VítorPublished 2021Using the chemical versatility of the benzo[ b ]thiophene motif, an extensive library of 24 (thio)urea receptors, with different binding properties and lipophilicities was prepared and included α,α-, α,β-, β,β-, β,γ-, α,γ-, ...Open AccessArticle -
Boundary flow on end-grafted PEG brushes
Charrault, E.; Lee, T.; Easton, C.D.; Neto, ChiaraPublished 2015-12-18We investigated the boundary conditions for flow of a Newtonian liquid over soft interfaces by measuring hydrodynamic drainage forces with colloid probe atomic force microscopy in a viscous liquid. The investigated soft ...Open AccessArticle
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