• Acridinone-based anion transporters 

      McNaughton, Daniel A.; Macreadie, Lauren K.; Gale, Philip A.
      Published 2021
      The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea ...
      Open Access
      Article
    • Activating ATRP Initiators to Incorporate End-Group Modularity into Photo-RAFT Polymerization 

      Hakobyan, Karen; McErlean, Christopher S.P.; Muellner, Markus
      Published 2020
      Heterogeneous photocatalysis is increasingly used in reversible deactivation radical polymerization (RDRP). In this study, we found that alkyl bromide redox chemistry typically found in atom transfer radical polymerization ...
      Open Access
      Article
    • Advances in Anion Receptor Chemistry 

      Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.
      Published 2020-01-01
      This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...
      Open Access
      Article
    • Advances in applied supramolecular technologies 

      Williams, George T.; Haynes, Cally J.E.; Fares, Mohamed; Caltagirone, Claudia; Hiscock, Jennifer; Gale, Philip A.
      Published 2021
      Supramolecular chemistry is a comparatively young field that to date has mainly been focused on building a foundation of fundamental understanding. With much progress in this area, researchers are seeking to apply this ...
      Open Access
      Article
    • Advances in fluorescent and colorimetric sensors for anionic species 

      McNaughton, Daniel A.; Fares, Mohamed; Picci, Giacomo; Gale, Philip A.; Caltagirone, Claudia
      Published 2021
      In this review we cover recent developments in fluorescent and colorimetric anion sensors. These systems employ a range of different non-covalent interactions including hydrogen- and halogen-bonding, Lewis acidic boron-based ...
      Open Access
      Preprint
    • Alkali metal modified P2 NaxMnO2: Crystal structure and application in sodium-ion batteries 

      Sehrawat, D; Rawal, A; Cheong, S; Avdeev, Maxim; Ling, Chris D; Kimpton, J A; Sharma, Neeraj
      Published 2020
      Sodium-ion batteries (NIBs) are an emerging alternative to lithium-ion batteries because of abundant sodium re-sources and the potentially lower cost. Here we report the Na0.7MnO2 solid-state synthesized at 1000 oC which ...
      Open Access
      Article
    • Amino acid-based squaramides for anion recognition 

      Elmes, Robert B. P.; Jolliffe, Katrina A.
      Published 2015-01-01
      Eight receptors 1–8 comprising an L-lysine scaffold modified at N- and C-termini with aliphatic alkyl chains and N,N0-alkyl amides, respectively, and bearing squaramide moieties on the amino acid side chain were synthesised ...
      Open Access
      Article
    • Anion binding in metal-organic frameworks 

      Wu, Xin; Gale, Philip A.
      Published 2021
      Despite commonly being used as the host for gases, solvents and other neutral molecules, metal-organic frameworks (MOFs) have received recent attention as supramolecular anion binding hosts with a broad range of environmental ...
      Open Access
      Preprint
    • Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs† 

      Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.
      Published 2019-10-01
      Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...
      Open Access
      Article
    • Anion receptor chemistry: Highlights from 2016 

      Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J.
      Published 2018-02-01
      This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.
      Open Access
      Article
    • Anion Recognition By Cyclic Peptides 

      Elmes, Robert B. P.; Jolliffe, Katrina A.
      Published 2015-01-01
      Anion binding selectivity can often be controlled by judicious arrangement of recognition moieties around an anion of interest. Indeed, nature takes advantage of large peptides/proteins to provide highly efficient and ...
      Open Access
      Article
    • Anion Recognition Using a Simple Cyclic Peptide 

      Sergeant, Genevieve; Jolliffe, Katrina
      Published 2020
      The head-to-tail cyclic hexapeptide, [cyclo(Val-Thr)3], was found to bind to a range of anions in DMSO-d6 with higher affinity for tetrahedral oxo-anions than halides. 1H NMR spectroscopy indicated that anion binding results ...
      Open Access
      Article
    • Anion transport and supramolecular medicinal chemistry 

      Gale, Philip A.; Davis, Jeffery T.; Quesada, Roberto
      Published 2017-01-01
      New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...
      Open Access
      Article
    • Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes 

      Dias, Christopher M.; Li, Hongyu; Valkenier, Hennie; Karagiannidis, Louise E.; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.
      Published 2017-12-01
      Ortho-Phenylene bis-ureas serve as anionophores in cells expressing halide-sensitive yellow fluorescent protein, as well as in synthetic vesicles. Activities can reach high levels, and are strongly dependent on the ...
      Open Access
      Article
    • Antifouling Properties of Liquid-Infused Riblets Fabricated by Direct Contactless Microfabrication 

      Fenati, Renzo A.; Quinn, Mitchell S.; Bilinksy, Henry C.; Neto, Chiara
      Published 2021
      The fabrication of riblets and surfaces structured with aligned grooves, by direct contactless microfabrication (DCM), and the ability of the riblets to function as lubricant-infused surfaces, is reported. Three types ...
      Open Access
      Article
    • Antiviral cyclic peptides targeting the main protease of SARS-CoV-2 

      Johansen-Leete, Jason; Ullrich, Sven; Fry, Sarah E.; Frkic, Rebecca; Bedding, Max J.; Aggarwal, Anupriya; Ashhurst, Anneliese S.; Ekanayake, Kasuni B.; Mahawaththa, Mithun C.; Sasi, Vishnu M.; Luedtke, Stephanie; Ford, Daniel J.; O'Donoghue, Anthony J.; Passioura, Toby; Larance, Mark; Otting, Gottfried; Turville, Stuart; Jackson, Colin J.; Nitsche, Christoph; Payne, Richard J.
      Published 2022
      Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (Mpro) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. Here we ...
      Article
    • Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter 

      Rawling, Tristan; MacDermott-Opeskin, Hugh; Roseblade, Ariane; Pazderka, Curtis; Clarke, Callum; Bourget, Kirsi; Wu, Xin; Lewis, William; Noble, Benjamin; Gale, Philip A.; O'Mara, Megan L.; Cranfield, Charles; Murray, Michael
      Published 2020
      Respiring mitochondria establish a proton gradient across the mitochondrial inner membrane (MIM) that is used to generate ATP. Protein-independent mitochondrial uncouplers collapse the proton gradient and disrupt ATP ...
      Open Access
      Article
    • Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids 

      Müllner, Markus; Yang, Kylie; Kaur, Amandeep; New, Elizabeth Joy
      Published 2018-06-08
      Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition ...
      Open Access
      Article
    • Beyond the Ionic Radii: A Multifaceted Approach to Understand Differences between the Structures of LnNbO4 and LnTaO4 Fergusonites 

      Mullens, Bryce; Saura-Múzquiz, Matilde; Marlton, Frederick; Avdeev, Maxim; Brand, Helen E. A.; Mondal, S.; Vaitheeswaran, G.; Kennedy, Brendan James
      Published 2023
      Synchrotron X-ray powder diffraction methods have been used to obtain accurate structures of the lanthanoid tantalates, LnTaO4, at room temperature. Three different structures are observed, depending on the size of the Ln ...
      Open Access
      Article
    • Binding and transport properties of a benzo[b]thiophene-based mono-(thio)urea library 

      Moiteiro, Cristina; Marques, Igor; Ryder, William G.; Cachatra, Vasco; Carvalho, Sílvia; Chen, Li-Jun; Goodfellow, Brian J.; Gale, Philip A.; Félix, Vítor
      Published 2021
      Using the chemical versatility of the benzo[ b ]thiophene motif, an extensive library of 24 (thio)urea receptors, with different binding properties and lipophilicities was prepared and included α,α-, α,β-, β,β-, β,γ-, α,γ-, ...
      Open Access
      Article