• Amino acid-based squaramides for anion recognition 

      Elmes, Robert B. P.; Jolliffe, Katrina A.
      Published 2015-01-01
      Eight receptors 1–8 comprising an L-lysine scaffold modified at N- and C-termini with aliphatic alkyl chains and N,N0-alkyl amides, respectively, and bearing squaramide moieties on the amino acid side chain were synthesised ...
      Open Access
      Article
    • Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs† 

      Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.
      Published 2019-10-01
      Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...
      Open Access
      Article
    • Anion receptor chemistry: Highlights from 2016 

      Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J.
      Published 2018-02-01
      This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.
      Open Access
      Article
    • Anion Recognition By Cyclic Peptides 

      Elmes, Robert B. P.; Jolliffe, Katrina A.
      Published 2015-01-01
      Anion binding selectivity can often be controlled by judicious arrangement of recognition moieties around an anion of interest. Indeed, nature takes advantage of large peptides/proteins to provide highly efficient and ...
      Open Access
      Article
    • Anion transport and supramolecular medicinal chemistry 

      Gale, Philip A.; Davis, Jeffery T.; Quesada, Roberto
      Published 2017-01-01
      New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...
      Open Access
      Article
    • Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes 

      Dias, Christopher M.; Li, Hongyu; Valkenier, Hennie; Karagiannidis, Louise E.; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P.
      Published 2017-12-01
      Ortho-Phenylene bis-ureas serve as anionophores in cells expressing halide-sensitive yellow fluorescent protein, as well as in synthetic vesicles. Activities can reach high levels, and are strongly dependent on the ...
      Open Access
      Article
    • Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids 

      Müllner, Markus; Yang, Kylie; Kaur, Amandeep; New, Elizabeth Joy
      Published 2018-06-08
      Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition ...
      Open Access
      Article
    • Boundary flow on end-grafted PEG brushes 

      Charrault, E.; Lee, T.; Easton, C.D.; Neto, Chiara
      Published 2015-12-18
      We investigated the boundary conditions for flow of a Newtonian liquid over soft interfaces by measuring hydrodynamic drainage forces with colloid probe atomic force microscopy in a viscous liquid. The investigated soft ...
      Open Access
      Article
    • Carborane functionalization of the aromatic network in chemically-synthesized graphene 

      Kahlert, Jan U.; Rawal, Aditya; Hook, James M.; Rendina, Louis M.; Choucair, Mohammad
      Published 2014-08-06
      The conjugated aromatic system of graphene was used to trap the reactive, boron-rich 1,2-carborane cluster. Functionalization of the graphene surface was confirmed by solid-state MAS 11B NMR spectroscopy and quantified by ...
      Open Access
      Article
    • Chain Collapse and Interfacial Slip of Polystyrene Films in Good/ Nonsolvent Vapor Mixtures 

      Al-Khayat, O.; Geraghty, K.; Shou, K.; Nelson, A.; Neto, Chiara
      Published 2016-02-08
      We investigated the dynamics and morphology of dewetting of metastable polystyrene films (thickness 75− 500 nm) cast on silicon substrates, upon exposure to vapors of a mixture of toluene, a good solvent, and ethanol, a ...
      Open Access
      Article
    • Control of nanoparticle formation using the constrained dewetting of polymer brushes 

      Lee, Thomas; Hendy, Shaun C.; Neto, Chiara
      Published 2015-01-14
      We have used coarse-grained molecular dynamics simulations to investigate the use of pinned micelles formed by the constrained dewetting of polymer brushes to act as a template for nanoparticle formation. The evaporation ...
      Open Access
      Article
    • Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate 

      Ariawan, A. Daryl; Webb, James E.A.; Howe, Ethan N.W.; Gale, Philip A.; Thordarson, Pall; Hunter, Luke
      Published 2017-02-01
      Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...
      Open Access
      Article
    • Deltamides and croconamides: Expanding the range of dual H-bond donors for selective anion recognition. 

      Zwicker, Vincent E.; Yuen, Karen K. Y.; Smith, David G.; Ho, Junming; Qin, Lei; Turner, Peter; Jolliffe, Katrina A.
      Published 2018-01-01
      Dual H-bond donors are widely used as recognition motifs in anion receptors. We report the synthesis of a library of dual H-bond receptors, incorporating the deltic and croconic acid derivatives, termed deltamides and ...
      Open Access
      Article
    • Dissecting the chloride–nitrate anion transport assay 

      Yang, Yufeng; Wu, Xin; Busschaert, Nathalie; Furuta, Hiroyuki; Gale, Philip A.
      Published 2017-07-01
      A systematic study of chloride vs. nitrate selectivity across six anion transporters has revealed a good correlation between the selectivities of their anion binding and membrane transport properties. This work reveals the ...
      Open Access
      Article
    • Durable Superhydrophobic Surfaces Via Spontaneous Wrinkling of Teflon 

      Scarratt, L.R.J.; Hoatson, B.S.; Wood, E.S.; Hawkett, B.S.; Neto, Chiara
      Published 2016-02-24
      We report the fabrication of both single-scale and hierarchical superhydrophobic surfaces, created by exploiting the spontaneous wrinkling of a rigid Teflon AF film on two types of shrinkable plastic substrates. Sub-100 ...
      Open Access
      Article
    • Effect of cholesterol on the dipole potential of lipid membranes 

      Clarke, Ronald J.
      Published 2019-01-01
      The membrane dipole potential, ψd, is an electrical potential difference with a value typically in the range 150 – 350 mV (positive in the membrane interior) which is located in the lipid headgroup region of the membrane, ...
      Open Access
      Article
    • Efficient radiosynthesis of a [18F]-phosphonium salt containing closo-carborane 

      Ioppolo, Joseph A.; Giboureau, Nicolas; Bhadbhade, Mohan; Morrison, Daniel E.; Kassiou, Michael; Rendina, Louis M.
      Published 2017-11-15
      An efficient synthesis of an 18F-labelled phosphonium salt containing closo-carborane is described. The preparation of this salt was attempted using both single-step and two-step protocols, with greater success found for ...
      Open Access
      Article
    • Expanding the breadth of 4-amino-1,8-naphthalimide photophysical properties through substitution of the naphthalimide core 

      Leslie, Kathryn G.; Jacquemin, Denia; New, Elizabeth J.; Jolliffe, Katrina A.
      Published 2018-01-01
      Fluorescent sensors that illuminate specific molecules and chemical events allow the selective and sensitive study of the cellular environment. At the centre of this technology lies the fluorescent reporter molecule, and ...
      Open Access
      Article
    • Fatty Acid Fueled Transmembrane Chloride Transport 

      Howe, Ethan N.W.; Gale, Philip A.
      Published 2019-06-21
      Generation of chemical gradients across biological membranes of cellular compartments is a hallmark of all living systems. Here we report a proof-of-concept prototype transmembrane pumping system in liposomes. The pump ...
      Open Access
      Article
    • The ferroelectric phase of CdTiO3. A powder neutron diffraction study. 

      Kennedy, Brendan J; Zhou, Qingdi; Avdeev, Maxim
      Published 2011-01-01
      The synthesis of bulk samples of polycrystalline CdTiO3 in both the rhombohedral ilmenite and orthorhombic perovskite forms is described and the structures of these have been refined using powder neutron diffraction data. ...
      Open Access
      Article