Now showing items 1-20 of 93

    • Amino acid-based squaramides for anion recognition 

      Elmes, Robert B. P.; Jolliffe, Katrina A. (Taylor and Francis, 2015)
      Eight receptors 1–8 comprising an L-lysine scaffold modified at N- and C-termini with aliphatic alkyl chains and N,N0-alkyl amides, respectively, and bearing squaramide moieties on the amino acid side chain were synthesised ...
    • Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs† 

      Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P. (Royal Society of Chemistry, 2019-10)
      Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...
    • Anion receptor chemistry: Highlights from 2016 

      Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J. (Elsevier, 2018-02)
      This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.
    • Anion Recognition By Cyclic Peptides 

      Elmes, Robert B. P.; Jolliffe, Katrina A. (Royal Society of Chemistry, 2015-01)
      Anion binding selectivity can often be controlled by judicious arrangement of recognition moieties around an anion of interest. Indeed, nature takes advantage of large peptides/proteins to provide highly efficient and ...
    • Anion transport and supramolecular medicinal chemistry 

      Gale, Philip A.; Davis, Jeffery T.; Quesada, Roberto (Royal Society of Chemistry, 2017)
      New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...
    • Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes 

      Dias, Christopher M.; Li, Hongyu; Valkenier, Hennie; Karagiannidis, Louise E.; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P. (Royal Society of Chemistry, 2017-12)
      Ortho-Phenylene bis-ureas serve as anionophores in cells expressing halide-sensitive yellow fluorescent protein, as well as in synthetic vesicles. Activities can reach high levels, and are strongly dependent on the ...
    • Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids 

      Müllner, Markus; Yang, Kylie; Kaur, Amandeep; New, Elizabeth Joy (Royal Society of Chemistry, 2018-06-08)
      Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition ...
    • Boundary flow on end-grafted PEG brushes 

      Charrault, E.; Lee, T.; Easton, C.D.; Neto, Chiara (Royal Society of Chemistry, 2015-12-18)
      We investigated the boundary conditions for flow of a Newtonian liquid over soft interfaces by measuring hydrodynamic drainage forces with colloid probe atomic force microscopy in a viscous liquid. The investigated soft ...
    • Carborane functionalization of the aromatic network in chemically-synthesized graphene 

      Kahlert, Jan U.; Rawal, Aditya; Hook, James M.; Rendina, Louis M.; Choucair, Mohammad (Royal Society of Chemistry, 2014-08-06)
      The conjugated aromatic system of graphene was used to trap the reactive, boron-rich 1,2-carborane cluster. Functionalization of the graphene surface was confirmed by solid-state MAS 11B NMR spectroscopy and quantified by ...
    • Chain Collapse and Interfacial Slip of Polystyrene Films in Good/ Nonsolvent Vapor Mixtures 

      Al-Khayat, O.; Geraghty, K.; Shou, K.; Nelson, A.; Neto, Chiara (ACS Publications, 2016-02-08)
      We investigated the dynamics and morphology of dewetting of metastable polystyrene films (thickness 75− 500 nm) cast on silicon substrates, upon exposure to vapors of a mixture of toluene, a good solvent, and ethanol, ...
    • Control of nanoparticle formation using the constrained dewetting of polymer brushes 

      Lee, Thomas; Hendy, Shaun C.; Neto, Chiara (RSC Publishing, 2015-01-14)
      We have used coarse-grained molecular dynamics simulations to investigate the use of pinned micelles formed by the constrained dewetting of polymer brushes to act as a template for nanoparticle formation. The evaporation ...
    • Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate 

      Ariawan, A. Daryl; Webb, James E.A.; Howe, Ethan N.W.; Gale, Philip A.; Thordarson, Pall; Hunter, Luke (Royal Society of Chemistry, 2017-02)
      Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...
    • Deltamides and croconamides: Expanding the range of dual H-bond donors for selective anion recognition. 

      Zwicker, Vincent E.; Yuen, Karen K. Y.; Smith, David G.; Ho, Junming; Qin, Lei; Turner, Peter; Jolliffe, Katrina A. (Wiley, 2018)
      Dual H-bond donors are widely used as recognition motifs in anion receptors. We report the synthesis of a library of dual H-bond receptors, incorporating the deltic and croconic acid derivatives, termed deltamides and ...
    • Dissecting the chloride–nitrate anion transport assay 

      Yang, Yufeng; Wu, Xin; Busschaert, Nathalie; Furuta, Hiroyuki; Gale, Philip A. (Royal Society of Chemistry, 2017-07)
      A systematic study of chloride vs. nitrate selectivity across six anion transporters has revealed a good correlation between the selectivities of their anion binding and membrane transport properties. This work reveals ...
    • Durable Superhydrophobic Surfaces Via Spontaneous Wrinkling of Teflon 

      Scarratt, L.R.J.; Hoatson, B.S.; Wood, E.S.; Hawkett, B.S.; Neto, Chiara (ACS Publications, 2016-02-24)
      We report the fabrication of both single-scale and hierarchical superhydrophobic surfaces, created by exploiting the spontaneous wrinkling of a rigid Teflon AF film on two types of shrinkable plastic substrates. Sub-100 ...
    • Effect of cholesterol on the dipole potential of lipid membranes 

      Clarke, Ronald J. (Springer, 2019)
      The membrane dipole potential, ψd, is an electrical potential difference with a value typically in the range 150 – 350 mV (positive in the membrane interior) which is located in the lipid headgroup region of the membrane, ...
    • Efficient radiosynthesis of a [18F]-phosphonium salt containing closo-carborane 

      Ioppolo, Joseph A.; Giboureau, Nicolas; Bhadbhade, Mohan; Morrison, Daniel E.; Kassiou, Michael; Rendina, Louis M. (Elsevier, 2017-11-15)
      An efficient synthesis of an 18F-labelled phosphonium salt containing closo-carborane is described. The preparation of this salt was attempted using both single-step and two-step protocols, with greater success found for ...
    • Expanding the breadth of 4-amino-1,8-naphthalimide photophysical properties through substitution of the naphthalimide core 

      Leslie, Kathryn G.; Jacquemin, Denia; New, Elizabeth J.; Jolliffe, Katrina A. (Wiley, 2018)
      Fluorescent sensors that illuminate specific molecules and chemical events allow the selective and sensitive study of the cellular environment. At the centre of this technology lies the fluorescent reporter molecule, and ...
    • Fatty Acid Fueled Transmembrane Chloride Transport 

      Howe, Ethan N.W.; Gale, Philip A. (American Chemical Society, 2019-06-21)
      Generation of chemical gradients across biological membranes of cellular compartments is a hallmark of all living systems. Here we report a proof-of-concept prototype transmembrane pumping system in liposomes. The pump uses ...
    • The ferroelectric phase of CdTiO3. A powder neutron diffraction study. 

      Kennedy, Brendan J; Zhou, Qingdi; Avdeev, Maxim (Elsevier, 2011)
      The synthesis of bulk samples of polycrystalline CdTiO3 in both the rhombohedral ilmenite and orthorhombic perovskite forms is described and the structures of these have been refined using powder neutron diffraction data. ...