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Penetration of Phospholipid Membranes by Poly-L-Lysine Depends on Cholesterol and Phospholipid Composition
Published 2020Clusters of positively-charged basic amino acid residues, particularly lysine, are known to promote the interaction of many peripheral membrane proteins with the cytoplasmic surface of the plasma membrane via electrostatic ...Open AccessArticle -
Polarity of the ATP binding site of the Na+,K+-ATPase, gastric H+,K+-ATPase and sarcoplasmic reticulum Ca2+-ATPase
Published 2020A fluorescence ratiometric method utilising the probe eosin Y is presented for estimating the ATP binding site polarity of P-type ATPases in different conformational states. The method has been calibrated by measurements ...Open AccessArticle -
Physiological roles of transverse lipid asymmetry of animal membranes
Published 2020The plasma membrane phospholipid distribution of animal cells is markedly asymmetric. Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are concentrated in the inner leaflet, whereas phosphatidylcholine (PC) and ...Open AccessArticle -
Transporter and protease mediated delivery of platinum complexes for precision oncology
Published 2019-01-01Precision approaches are rapidly becoming the norm in the treatment of cancer and this is already impacting on the way platinum complexes are used. In this commentary, we will argue that there is the potential for platinum ...Open AccessArticle -
Syntheses and reductions of C-dimesitylboryl-1,2-dicarba-closo-dodecaboranes
Published 2015-04-24Two C-dimesitylboryl-1,2-dicarba-closo-dodecaboranes, 1-(BMes2)-2-R-1,2-C2B10H10 (1, R = H, 2, R = Ph), were synthesised by lithiation of 1,2-dicarba-closo-dodecaborane and 1-phenyl-1,2-dicarba-closo-dodecaborane, respectively, ...Open AccessArticle