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Recent Submissions

  • Discovery of Cyclic Peptide Ligands to the SARS-CoV_2 Spike Protein Using mRNA Display 

    Norman, Alexander; Franck, Charlotte; Christie, Mary; Hawkins, Paige M. E.; Patel, Karishma; Ashhurst, Anneliese S.; Aggarwal, Anupriya; Low, Jason K. K.; Siddiquee, Rezwan; Ashley, Caroline L.; Steain, Megan; Triccas, James A.; Turville, Stuart; Mackay, Joel P.; Passioura, Toby; Payne, Richard J.
    Published 2021
    The COVID-19 pandemic, caused by SARS-CoV-2, has led to substantial morbidity, mortality, and disruption globally. Cellular entry of SARS-CoV-2 is mediated by the viral spike protein, and affinity ligands to this surface ...
    Article
  • Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display 

    Johansen-Leete, Jason; Ullrich, Sven; Fry, Sarah E.; Frkic, Rebecca; Bedding, Max J.; Aggarwal, Anupriya; Ashhurst, Anneliese S.; Ekanayake, Kasuni B.; Mahawaththa, Mithun C.; Sasi, Vishnu M.; Passioura, Toby; Larance, Mark; Otting, Gottfried; Turville, Stuart; Jackson, Colin J.; Nitsche, Christoph; Payne, Richard J.
    Published 2021
    Abstract Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (M pro ) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. ...
    Preprint
  • Toward the identification of potential _-ketoamide covalent inhibitors for sars-cov-2 main protease: Fragment-based drug design and mm-pbsa calculations 

    El Hassab, M.A.; Fares, M.; Amin, M.K.A.-H.; Al-Rashood, S.T.; Alharbi, A.; Eskandrani, R.O.; Alkahtani, H.M.; Eldehna, W.M.
    Published 2021
    Since December 2019, the world has been facing the outbreak of the SARS-CoV-2 pandemic that has infected more than 149 million and killed 3.1 million people by 27 April 2021, according to WHO statistics. Safety measures ...
    Article
  • Cylindrical Zwitterionic Particles via Interpolyelectrolyte Complexation on Molecular Polymer Brushes 

    Muellner, Markus; Nonappa; Mahon, Clare S.; Pelras, Theophile
    Published 2020
    The fabrication of macromolecular architectures with high aspect ratio and well‐defined internal and external morphologies remains a challenge. The combination of template chemistry and self‐assembly concepts to construct ...
    Open Access
    Article
  • Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials 

    Tse, Edwin G.; Houston, Sevan D.; Williams, Craig M.; Savage, G. Paul; Rendina, Louis M.; Hallyburton, Irene; Anderson, Mark; Sharma, Raman; Walker, Gregory S.; Obach, R. Scott; Todd, Matthew H.
    Published 2020
    The replacement of one chemical motif with another that is broadly similar is a common method in medicinal chemistry to modulate the physical and biological properties of a molecule (i.e., bioisosterism). In recent years, ...
    Open Access
    Article

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