Acridinone-based anion transporters
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Open Access
Type
ArticleAbstract
The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the
development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea motif which had
previously shown promise as an anion sensor and expand the series of compounds by appending a variety of electron-withdrawing groups to the peripheral phenyl moieties. High levels of activity were achieved by the most effective
compounds in the series, which facilitated strictly electroneutral transport.The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the
development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea motif which had
previously shown promise as an anion sensor and expand the series of compounds by appending a variety of electron-withdrawing groups to the peripheral phenyl moieties. High levels of activity were achieved by the most effective
compounds in the series, which facilitated strictly electroneutral transport.
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Date
2021Source title
Organic & Biomolecular ChemistryVolume
19Publisher
Royal Society of ChemistryFunding information
ARC DP200100453Licence
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0Faculty/School
Faculty of Science, School of ChemistryThe University of Sydney Multidisciplinary Centres and Institutes , The University of Sydney Nano Institute
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