Recent Submissions

  • Transporter and protease mediated delivery of platinum complexes for precision oncology 

    Hambley, Trevor William
    Published 2019-01-01
    Precision approaches are rapidly becoming the norm in the treatment of cancer and this is already impacting on the way platinum complexes are used. In this commentary, we will argue that there is the potential for platinum ...
    Open Access
    Article
  • Syntheses and reductions of C-dimesitylboryl-1,2-dicarba-closo-dodecaboranes 

    Kahlert, Jan; Böhling, Lena; Brockhinke, Andreas; Stammler, Hans-Georg; Neumann, Beate; Rendina, Louis M.; Low, Paul J.; Weber, Lothar; Fox, Mark A.
    Published 2015-04-24
    Two C-dimesitylboryl-1,2-dicarba-closo-dodecaboranes, 1-(BMes2)-2-R-1,2-C2B10H10 (1, R = H, 2, R = Ph), were synthesised by lithiation of 1,2-dicarba-closo-dodecaborane and 1-phenyl-1,2-dicarba-closo-dodecaborane, respectively, ...
    Open Access
    Article
  • The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane 

    Austin, Christopher J. D.; Kahlert, Jan; Issa, Fatiah; Reed, John H.; Smith, Jason R.; Ioppolo, Joseph A.; Ong, Jennifer A.; Jamie, Joanne F.; Hibbs, David; Rendina, Louis M.
    Published 2014-04-22
    Indoleamine-2,3-dioxygenase-1 (IDO1) is a critical immunoregulatory enzyme responsible for the metabolism of tryptophan during inflammation and disease. Based upon a pyranonaphthoquinone framework, the first examples of ...
    Open Access
    Article
  • Efficient radiosynthesis of a [18F]-phosphonium salt containing closo-carborane 

    Ioppolo, Joseph A.; Giboureau, Nicolas; Bhadbhade, Mohan; Morrison, Daniel E.; Kassiou, Michael; Rendina, Louis M.
    Published 2017-11-15
    An efficient synthesis of an 18F-labelled phosphonium salt containing closo-carborane is described. The preparation of this salt was attempted using both single-step and two-step protocols, with greater success found for ...
    Open Access
    Article
  • Site-specific synthesis of a hybrid boron-graphene salt 

    Kahlert, Jan U.; Austin, Christopher J. D.; Hall, Andrew J.; Rawal, Aditya; Hook, James M.; Rendina, Louis M.; Choucair, Mohammad
    Published 2016-01-01
    We report the first example of an ionic graphene salt containing boron. An anionic charge is introduced to the graphene surface by means of 7,8-nido-[C2B9H11]− carborane clusters covalently and electronically bound to the ...
    Open Access
    Article

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