Recent Submissions

  • Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs† 

    Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P. (Royal Society of Chemistry, 2019-10)
    Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...
  • Effect of cholesterol on the dipole potential of lipid membranes 

    Clarke, Ronald J. (Springer, 2019)
    The membrane dipole potential, ψd, is an electrical potential difference with a value typically in the range 150 – 350 mV (positive in the membrane interior) which is located in the lipid headgroup region of the membrane, ...
  • New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas 

    Jowett, Laura A.; Howe, Ethan N.W.; Wu, Xin; Busschaert, Nathalie; Gale, Philip A. (Wiley VCH, 2018-06-19)
    The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport ...
  • Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations 

    Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, Vítor (Royal Society of Chemistry, 2018-06-29)
    A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...
  • Real-Time Recording of the Cellular Effects of the Anion Transporter Prodigiosin 

    Cheung, Shane; Wu, Dan; Daly, Harrison C.; Busschaert, Nathalie; Morgunova, Marina; Simpson, Jeremy C.; Scholz, Dimitri; Gale, Philip A.; O'Shea, Donal F. (Cell Press, 2018-04-12)
    The unraveling of the cellular effects of anion transporters is key to their potential development as apoptosis-inducing or autophagy-disrupting therapeutics. Here, we conducted a systematic study of the cellular responses ...

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