Browsing School of Chemistry by subject "030302"
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Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs†
Published 2019-10-01Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...Open AccessArticle -
Anion receptor chemistry: Highlights from 2016
Published 2018-02-01This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.Open AccessArticle -
Anion transport and supramolecular medicinal chemistry
Published 2017-01-01New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...Open AccessArticle -
Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes
Published 2017-12-01Ortho-Phenylene bis-ureas serve as anionophores in cells expressing halide-sensitive yellow fluorescent protein, as well as in synthetic vesicles. Activities can reach high levels, and are strongly dependent on the ...Open AccessArticle -
Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate
Published 2017-02-01Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...Open AccessArticle -
Dissecting the chloride–nitrate anion transport assay
Published 2017-07-01A systematic study of chloride vs. nitrate selectivity across six anion transporters has revealed a good correlation between the selectivities of their anion binding and membrane transport properties. This work reveals the ...Open AccessArticle -
Fatty Acid Fueled Transmembrane Chloride Transport
Published 2019-06-21Generation of chemical gradients across biological membranes of cellular compartments is a hallmark of all living systems. Here we report a proof-of-concept prototype transmembrane pumping system in liposomes. The pump ...Open AccessArticle -
Fluorescent squaramides as anion receptors and transmembrane anion transporters
Published 2018-01-01A series of squaramide-based anion transporters functionalised with the 1,8-naphthalimide fluorophore has been developed for improved ionophoric activity and fluorescent imaging in cells.Open AccessArticle -
Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport
Published 2018-01-01A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate their mechanism of action using anion transport assays in cells ...Open AccessArticle -
Fluorinated tripodal receptors for potentiometric chloride detection in biological fluids
Published 2017-07-01Fluorinated tripodal compounds were recently reported to be efficient transmembrane transporters for a series of inorganic anions. In particular, this class of receptors has been shown to be suitable for the effective ...Open AccessArticle -
Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations
Published 2018-06-29A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...Open AccessArticle -
Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations
Published 2018-01-01A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...Open AccessArticle -
Hydroquinone-Based Anion Receptors for Redox-Switchable Chloride Binding
Published 2019-07-11A series of chloride receptors has been synthesized containing an amide hydrogen bonding site and a hydroquinone motif. It was anticipated that oxidation of the hydroquinone unit to quinone would greatly the diminish ...Open AccessArticle -
Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents
Published 2017-01-01Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H+/Cl− ...Open AccessArticle -
Investigating the Influence of Steric Hindrance on Selective Anion Transport
Published 2019-04-02A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied. Overall, increasing the steric bulk of the substituents ...Open AccessArticle -
New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas
Published 2018-06-19The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism ...Open AccessArticle -
Real-Time Recording of the Cellular Effects of the Anion Transporter Prodigiosin
Published 2018-04-12The unraveling of the cellular effects of anion transporters is key to their potential development as apoptosis-inducing or autophagy-disrupting therapeutics. Here, we conducted a systematic study of the cellular responses ...Open AccessPreprint -
Selective sensing of pyrophosphate in physiological media using zinc(II)dipicolylamino-functionalised peptides
Published 2015-01-01A series of linear peptide based anion receptors, in which the distance between the bis[zinc(II)dipicolylamine] binding sites and the peptide backbone was varied systematically, was prepared and their anion binding ability ...Open AccessArticle -
Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux
Published 2019-02-01Cystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate ...Open AccessArticle -
Tetraurea Macrocycles: Aggregation-Driven Binding of Chloride in Aqueous Solutions
Published 2019-05-09Artificial receptors that recognize anionic species via non-covalent interactions have a wide range of biomedical, industrial, and environmental applications. A major challenge in this area of research is to achieve ...Open AccessArticle