|Title:||Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate|
|Authors:||Ariawan, A. Daryl|
Webb, James E.A.
Howe, Ethan N.W.
Gale, Philip A.
|Publisher:||Royal Society of Chemistry|
|Citation:||A. Daryl Ariawan, J. E. A. Webb, E. N. W. Howe, P. A. Gale, P. Thordarson and L. Hunter, Org. Biomol. Chem., 2017, 15, 2962 DOI: 10.1039/c7ob00316a|
|Abstract:||Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth inhibition assays, a result that runs contrary to a previous report. However, we find that 1 functions as a promiscuous host molecule in a variety of anion-binding interactions, with high affinity particularly for phosphate and pyrophosphate. We also show that a series of rigidified, backbone-fluorinated analogues of 1 displays altered affinity for chloride ions.|
|Rights and Permissions:||Reproduced from Organic & Biomolecular Chemistry with permission from the Royal Society of Chemistry.|
|Type of Work:||Article|
|Type of Publication:||Post-print|
|Appears in Collections:||Research Papers and Publications. Chemistry|
|Revised manuscript 4.3.17.pdf||1.62 MB||Adobe PDF|
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