New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas
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Open Access
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ArticleAbstract
The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism and selectivity of this important class of transporters. Specifically, we report the chloride and nitrate transport selectivity of these systems and quantify sulfate transport to determine EC50 values for sulfate transport for the first time. Two new assays were developed to study bicarbonate transport allowing accurate quantification of chloride/bicarbonate exchange.The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism and selectivity of this important class of transporters. Specifically, we report the chloride and nitrate transport selectivity of these systems and quantify sulfate transport to determine EC50 values for sulfate transport for the first time. Two new assays were developed to study bicarbonate transport allowing accurate quantification of chloride/bicarbonate exchange.
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Date
2018-06-19Publisher
Wiley VCHCitation
Jowett, L. A., Howe, E. N. W., Wu, X., Busschaert, N., & Gale, P. A. (2018). New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas. Chemistry - A European Journal, 24(41), 10475–10487. https://doi.org/10.1002/chem.201801463Share