Browsing Research Publications and Outputs by title
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The Health and Structural Consequences of Acute Knee Injuries Involving Rupture of the Anterior Cruciate Ligament
Published 2013-02-01Although there is an abundance of literature regarding the development of knee osteoarthritis after rupture of the anterior cruciate ligament (ACL), the mechanism underlying this link is not clear. Recent studies have ...Open AccessArticle -
Imaging Biomarker Validation and Qualification Report: 6th OARSI Workshop on Imaging in Osteoarthritis Combined with 3rd OA Biomarkers Workshop.
Published 2013-07-01Summary The sixth Osteoarthritis Research Society International (OARSI) Workshop on Imaging in Osteoarthritis combined with the third osteoarthritis (OA) Biomarkers Workshop is the first to bring together the imaging and ...Open AccessArticle -
Imaging of Osteoarthritis
Published 2013-02-01Osteoarthritis (OA) is the most prevalent joint disorder in the elderly, and there is no effective treatment. Imaging is essential for evaluating the synovial joint structures (including cartilage, meniscus, subchondral ...Open AccessArticle -
Lifetime risk and age of diagnosis of symptomatic knee osteoarthritis in the US
Published 2013-05-01OBJECTIVE: To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population. METHODS: We estimated the incidence ...Open AccessArticle -
Long term joint consequences of sporting activity: preventing and managing osteoarthritis in the athlete
Published 2012-07-31Sports participation is associated with an increased risk of future osteoarthritis (OA), much of which results from joint injury. No strong evidence exists that moderate sporting activity in the presence of normal joints ...Open AccessArticle -
Management of osteoarthritis of the knee
Published 2012-07-30Osteoarthritis is a chronic disease; management should be patient centred and coordinated, with attention to modifiable risk factors and comorbidities Focus on conservative non-drug treatment, particularly exercise; for ...Open AccessArticle -
The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features
Published 2012-11-01This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled ...Open AccessArticle -
Morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis of the knee.
Published 2012-02-01OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...Open AccessArticle -
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
Published 2013-07-01OBJECTIVE: Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. ...Open AccessArticle -
Osteoarthritis Preface
Published 2013-02-01Osteoarthritis (OA) is the leading cause of disability among older adults. It is an incredibly prevalent condition affecting upward of 1 in 8 adults. Societal trends in aging, obesity, and increasing joint injury will lead ...Open AccessArticle -
Osteoarthritis: What does imaging tell us about its etiology.
Published 2012-11-01Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. Due to an aging population and increasing obesity, the incidence of OA is rising. The etiology of OA is multifactorial and complex; ...Open AccessArticle -
Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review
Published 2007-01-01Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ...Open AccessArticle -
Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells
Published 2006-01-01Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ...Open AccessArticle -
Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears.
Published 2012-02-01OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...Open AccessArticle -
Presence and Extent of Severe Facet Joint Osteoarthritis Are Associated with Back Pain in Older Adults
Published 2013-09-01Objective To determine whether the presence and extent of severe lumbar facet joint osteoarthritis (OA) are associated with back pain in older adults, accounting for disc height narrowing and other covariates. Design ...Open AccessArticle -
Prevalence of Anatomic Impediments to Interlaminar Lumbar Epidural Steroid Injection
Published 2012-02-01OBJECTIVE: To determine the prevalence of anatomic impediments to interlaminar lumbar epidural steroid injection (LESI) in a community-based population. DESIGN: Cross-sectional observational study. SETTING: Community-based. ...Open AccessArticle -
Purine-Rich Foods Intake and Recurrent Gout Attacks
Published 2012-09-01OBJECTIVE: To examine and quantify the relation between purine intake and the risk of recurrent gout attacks among gout patients. METHODS: The authors conducted a case-crossover study to examine associations of a set of ...Open AccessArticle -
Quantification of Walking Ability in Participants with Neurogenic Claudication from Lumbar Spinal Stenosis – A Comparative Study
Published 2012-02-01Background context Walking limitations caused by neurogenic claudication (NC) are typically assessed with self-reported measures, although objective evaluation of walking using motorized treadmill test (MTT) or self-paced ...Open AccessArticle -
Quantitative Assessment of Abdominal Aortic Calcification and Disk Height Loss: The Framingham Study
Published 2012-04-01Abstract Background context Vascular disease has been proposed as a risk factor for disc height loss (DHL). Purpose To examine the relationship between quantitative measures of abdominal aortic calcifications (AACs) ...Open AccessArticle -
Quantitative MRI measures of cartilage predict knee replacement: a case-control study from the Osteoarthritis Initiative.
Published 2013-05-01OBJECTIVE: Knee osteoarthritis commonly requires joint replacement, substantially reduces quality of life and increases healthcare utilisation and costs. This study aimed to identify whether quantitative measures of articular ...Open AccessArticle