Browsing Research Publications and Outputs by publication year
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Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells
Published 2006-01-01Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ...Open AccessArticle -
Understanding cisplatin resistance using cellular models
Published 2007-01-01Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of ...Open AccessArticle -
A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship
Published 2007-01-01We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for 1) cell models of acquired drug ...Open AccessArticle -
Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review
Published 2007-01-01Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ...Open AccessArticle -
The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston–Leeds Osteoarthritis Knee Score)
Published 2007-05-01Aim: MRI provides unparalleled visualisation of all the anatomical structures involved in the osteoarthritis (OA) process. There is a need for reliable methods of quantifying abnormalities of these structures. The aim of ...Open AccessArticle -
A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome
Published 2008-02-19Transfected human ASK1 produces a 150kDa protein. However, we have detected endogenous ASK1 predominantly as 39kDa and 50kDa C-terminal and 75kDa and 110kDa N-terminal fragments in a panel of non-transfected cancer cell ...Open AccessArticle -
ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair
Published 2008-06-25Background: The H69CIS200 and H69OX400 cell lines are novel models of low- level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the ...Open AccessArticle -
Regrowth resistance: low-level platinum resistance mediated by rapid recovery from platinum-induced cell-cycle arrest
Published 2009-01-01The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum drug resistance developed from H69 human small-cell lung cancer cells with eight 4-day treatments of 200 ng/ml cisplatin and 400 ng/ml oxaliplatin, ...Open AccessBook chapter -
Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy.
Published 2009-01-01Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer. Methods: Medline was searched for 1) Cell models of ...Open AccessBook chapter -
A Randomized Trial of Realignment Therapy for Treatment of Medial Tibiofemoral Osteoarthritis
Published 2009-09-01Objectives: The objective of this 30-week randomized crossover trial was to determine whether a multi-modal realignment therapy would be successful in relieving pain and improving function among persons with medial ...Open AccessConference poster -
A Randomized Trial of Patellofemoral Bracing for Treatment of Patellofemoral Osteoarthritis
Published 2011-07-01Purpose The number of effective knee osteoarthritis (OA) interventions, especially those tailored to specific compartmental involvement, are small. The objective of this study was to determine the efficacy of a realigning ...Open AccessArticle -
Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population
Published 2011-09-13Background- Prior studies that have concluded that disk degeneration uniformly precedes facet degeneration have been based on convenience samples of individuals with low back pain. We conducted a study to examine whether ...Open AccessArticle -
Acute low back pain is marked by variability: An internet-based pilot study
Published 2011-10-05BACKGROUND: Pain variability in acute LBP has received limited study. The objectives of this pilot study were to characterize fluctuations in pain during acute LBP, to determine whether self-reported 'flares' of pain ...Open AccessPublisher version -
Prevalence of Anatomic Impediments to Interlaminar Lumbar Epidural Steroid Injection
Published 2012-02-01OBJECTIVE: To determine the prevalence of anatomic impediments to interlaminar lumbar epidural steroid injection (LESI) in a community-based population. DESIGN: Cross-sectional observational study. SETTING: Community-based. ...Open AccessArticle -
Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears.
Published 2012-02-01OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...Open AccessArticle -
Quantification of Walking Ability in Participants with Neurogenic Claudication from Lumbar Spinal Stenosis – A Comparative Study
Published 2012-02-01Background context Walking limitations caused by neurogenic claudication (NC) are typically assessed with self-reported measures, although objective evaluation of walking using motorized treadmill test (MTT) or self-paced ...Open AccessArticle -
Morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis of the knee.
Published 2012-02-01OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...Open AccessArticle -
Quantitative Assessment of Abdominal Aortic Calcification and Disk Height Loss: The Framingham Study
Published 2012-04-01Abstract Background context Vascular disease has been proposed as a risk factor for disc height loss (DHL). Purpose To examine the relationship between quantitative measures of abdominal aortic calcifications (AACs) ...Open AccessArticle -
Side Differences of Thigh Muscle Cross-Sectional Areas and Maximal Isometric Muscle Force in Bilateral Knees with the Same Radiographic Disease Stage, but Unilateral Frequent Pain – Data from the Osteoarthritis Initiative
Published 2012-06-01Objective To determine whether anatomical thigh muscle cross-sectional areas (MCSAs) and strength differ between osteoarthritis (OA) knees with frequent pain compared with contra-lateral knees without pain, and to examine ...Open AccessArticle -
Risk Factors for Medial Meniscus Posterior Root Tear
Published 2012-07-01Background: Medial meniscus posterior root tears (MMPRT) have a different clinical effect from other types of meniscal tears. These tears are very common among Asian people and may be related to the frequent use of postures ...Open AccessArticle