Browsing Research Publications and Outputs by title
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A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome
Published 2008-02-19Transfected human ASK1 produces a 150kDa protein. However, we have detected endogenous ASK1 predominantly as 39kDa and 50kDa C-terminal and 75kDa and 110kDa N-terminal fragments in a panel of non-transfected cancer cell ...Open AccessArticle -
Acute low back pain is marked by variability: An internet-based pilot study
Published 2011-10-05BACKGROUND: Pain variability in acute LBP has received limited study. The objectives of this pilot study were to characterize fluctuations in pain during acute LBP, to determine whether self-reported 'flares' of pain ...Open AccessPublisher version -
Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea
Published 2013-05-01Objective: To describe the frequency of bonemarrowlesions (BMLs) detected bymagnetic resonance imaging (MRI), and to examine the association of BMLs with knee pain severity in community residents in Korea. Methods: ...Open AccessArticle -
The association between reduced knee joint proprioception and medial meniscal abnormalities using MRI in knee osteoarthritis: results from the Amsterdam osteoarthritis cohort.
Published 2013-05-01BACKGROUND: Osteoarthritis (OA) of the knee is characterized by pain and activity limitations. In knee OA, proprioceptive accuracy is reduced and might be associated with pain and activity limitations. Although causes of ...Open AccessArticle -
Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?
Published 2013-05-01OBJECTIVE: Disease-modifying osteoarthritis drugs (DMOADs) are under development. Our goal was to determine efficacy, toxicity, and cost thresholds under which DMOADs would be a cost-effective knee OA treatment. DESIGN: ...Open AccessArticle -
Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population
Published 2011-09-13Background- Prior studies that have concluded that disk degeneration uniformly precedes facet degeneration have been based on convenience samples of individuals with low back pain. We conducted a study to examine whether ...Open AccessArticle -
Effect of combined conservative therapies on clinical outcomes in patients with thumb base osteoarthritis (COMBO) dataset
Published 2023-05-05We will share the data of 196 participants including demographics, clinical characteristics, and outcome measures at baseline, weeks 2, 6 and 12.Open AccessDataset -
EFFECTS OF INTENSIVE DIET AND EXERCISE ON KNEE JOINT LOADS, INFLAMMATION, AND CLINICAL OUTCOMES AMONG OVERWEIGHT AND OBESE ADULTS WITH KNEE OSTEOARTHRITIS
Published 2013-01-01Importance Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. Objective To determine whether a ≥10% reduction in body weight ...Open AccessArticle -
ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair
Published 2008-06-25Background: The H69CIS200 and H69OX400 cell lines are novel models of low- level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the ...Open AccessArticle -
Growth in emergency department self-harm or suicidal ideation presentations in young people: Comparing trends before and since the COVID-19 first wave in New South Wales, Australia.
Published 2022INTRODUCTION: Self-harm presentations in children and young people have increased internationally over the last decade. The COVID-19 pandemic has the potential to worsen these trends. OBJECTIVE: To describe trends in ...Article -
The Health and Structural Consequences of Acute Knee Injuries Involving Rupture of the Anterior Cruciate Ligament
Published 2013-02-01Although there is an abundance of literature regarding the development of knee osteoarthritis after rupture of the anterior cruciate ligament (ACL), the mechanism underlying this link is not clear. Recent studies have ...Open AccessArticle -
Imaging Biomarker Validation and Qualification Report: 6th OARSI Workshop on Imaging in Osteoarthritis Combined with 3rd OA Biomarkers Workshop.
Published 2013-07-01Summary The sixth Osteoarthritis Research Society International (OARSI) Workshop on Imaging in Osteoarthritis combined with the third osteoarthritis (OA) Biomarkers Workshop is the first to bring together the imaging and ...Open AccessArticle -
Imaging of Osteoarthritis
Published 2013-02-01Osteoarthritis (OA) is the most prevalent joint disorder in the elderly, and there is no effective treatment. Imaging is essential for evaluating the synovial joint structures (including cartilage, meniscus, subchondral ...Open AccessArticle -
Lifetime risk and age of diagnosis of symptomatic knee osteoarthritis in the US
Published 2013-05-01OBJECTIVE: To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population. METHODS: We estimated the incidence ...Open AccessArticle -
Long term joint consequences of sporting activity: preventing and managing osteoarthritis in the athlete
Published 2012-07-31Sports participation is associated with an increased risk of future osteoarthritis (OA), much of which results from joint injury. No strong evidence exists that moderate sporting activity in the presence of normal joints ...Open AccessArticle -
Management of osteoarthritis of the knee
Published 2012-07-30Osteoarthritis is a chronic disease; management should be patient centred and coordinated, with attention to modifiable risk factors and comorbidities Focus on conservative non-drug treatment, particularly exercise; for ...Open AccessArticle -
The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features
Published 2012-11-01This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled ...Open AccessArticle -
Morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis of the knee.
Published 2012-02-01OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...Open AccessArticle -
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
Published 2013-07-01OBJECTIVE: Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. ...Open AccessArticle