Now showing items 1-20 of 43

    • A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome 

      Stordal, Britta; Davey, Ross (Taylor & Francis, 2008-02-19)
      Transfected human ASK1 produces a 150kDa protein. However, we have detected endogenous ASK1 predominantly as 39kDa and 50kDa C-terminal and 75kDa and 110kDa N-terminal fragments in a panel of non-transfected cancer cell ...
    • Acute low back pain is marked by variability: An internet-based pilot study 

      Suri, Pradeep; Rainville, James; Fitzmaurice, Garrett M; Katz, Jeffrey N.; Jamison, Robert N; Martha, Julia; Hartigan, Carol; Limke, Janet; Jouve, Cristin; Hunter, David J. (BMC Musculoskeletal Disorders, 2011-10-05)
      BACKGROUND: Pain variability in acute LBP has received limited study. The objectives of this pilot study were to characterize fluctuations in pain during acute LBP, to determine whether self-reported 'flares' of pain ...
    • Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea 

      Kim, I. J.; Kim, D. H.; Jung, J. Y.; Song, Y. W.; Guermazi, Ali; Crema, M. D.; Hunter, David J.; Kim, H. A. (Osteoarthritis and Cartilage, 2013-05-01)
      Objective: To describe the frequency of bonemarrowlesions (BMLs) detected bymagnetic resonance imaging (MRI), and to examine the association of BMLs with knee pain severity in community residents in Korea. Methods: ...
    • The association between reduced knee joint proprioception and medial meniscal abnormalities using MRI in knee osteoarthritis: results from the Amsterdam osteoarthritis cohort. 

      van der Esch, Martin; Knoop, Jesper; Hunter, David J.; Klein, Jan-Paul; van der Leeden, Marike; Knol, Dirk L; Reiding, Dick; Vooreman, Ramon E; Gerritsen, Martijn; Roorda, Leo D; Lems, Willem F; Dekker, Joost (Elsevier, 2013-05)
      BACKGROUND: Osteoarthritis (OA) of the knee is characterized by pain and activity limitations. In knee OA, proprioceptive accuracy is reduced and might be associated with pain and activity limitations. Although causes of ...
    • Disease-modifying drugs for knee osteoarthritis: can they be cost-effective? 

      Losina, Elena; Daigle, Meghan E.; Reichmann, William M.; Suter, Lisa G.; Hunter, David J.; Solomon, Daniel H.; Walensky, Rochelle P.; Jordan, Joanne M.; Burbine, Sara A.; Patiel, A. Daniel; Katz, Jeffrey N. (Elsevier, 2013-05)
      OBJECTIVE: Disease-modifying osteoarthritis drugs (DMOADs) are under development. Our goal was to determine efficacy, toxicity, and cost thresholds under which DMOADs would be a cost-effective knee OA treatment. DESIGN: ...
    • Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population 

      Suri, Pradeep; Miyakoshi, Asako; Hunter, David J.; Jarvik, Jeffrey G; Rainville, James; Guermazi, Ali; Li, Ling; Katz, Jeffrey N. (BMC Musculoskeletal Disorders, 2011-09-13)
      Background- Prior studies that have concluded that disk degeneration uniformly precedes facet degeneration have been based on convenience samples of individuals with low back pain. We conducted a study to examine whether ...
    • EFFECTS OF INTENSIVE DIET AND EXERCISE ON KNEE JOINT LOADS, INFLAMMATION, AND CLINICAL OUTCOMES AMONG OVERWEIGHT AND OBESE ADULTS WITH KNEE OSTEOARTHRITIS 

      Messier, Stephen P; Mihalko, Shannon L; Legault, Claudine; Miller, Gary D.; Nicklas, Barbara J.; DeVita, Paul; Beavers, Daniel P; Hunter, David J.; Lyles, Mary F.; Eckstein, Felix; Williamson, Jeff D; Carr, J. Jeffery; Guermazi, Ali; Loeser, Richard F. (The Journal of the American Medical Association, 2013)
      Importance Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. Objective To determine whether a ≥10% reduction in body ...
    • ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair 

      Stordal, Britta; Davey, Ross (Springer Berlin / Heidelberg, 2008-06-25)
      Background: The H69CIS200 and H69OX400 cell lines are novel models of low- level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather ...
    • The Health and Structural Consequences of Acute Knee Injuries Involving Rupture of the Anterior Cruciate Ligament 

      Riordan, Edward A; Frobell, Richard B; Roemer, Frank W.; Hunter, David J. (Elsevier, 2013-02)
      Although there is an abundance of literature regarding the development of knee osteoarthritis after rupture of the anterior cruciate ligament (ACL), the mechanism underlying this link is not clear. Recent studies have ...
    • Imaging Biomarker Validation and Qualification Report: 6th OARSI Workshop on Imaging in Osteoarthritis Combined with 3rd OA Biomarkers Workshop. 

      Hunter, David J.; Eckstein, Felix; Kraus, Virginia Byers; Lousina, Elena; Sandell, Linda; Guermazi, Ali (Elsevier, 2013-07)
      Summary The sixth Osteoarthritis Research Society International (OARSI) Workshop on Imaging in Osteoarthritis combined with the third osteoarthritis (OA) Biomarkers Workshop is the first to bring together the imaging ...
    • Imaging of Osteoarthritis 

      Guermazi, Ali; Hayashi, Daichi; Eckstein, Felix; Hunter, David J.; Duryea, Jeff; Roemer, Frank W. (Elsevier, 2013-02)
      Osteoarthritis (OA) is the most prevalent joint disorder in the elderly, and there is no effective treatment. Imaging is essential for evaluating the synovial joint structures (including cartilage, meniscus, subchondral ...
    • Lifetime risk and age of diagnosis of symptomatic knee osteoarthritis in the US 

      Losina, Elena; Weinstein, Alexander M.; Reichmann, William M.; Burbine, Sara A.; Solomon, Daniel H.; Daigle, Meghan E.; Rome, Benjamin N.; Chen, Stephanie P.; Hunter, David J.; Suter, Lisa G.; Jordan, Joanne M.; Katz, Jeffrey N. (Willey, 2013-05)
      OBJECTIVE: To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population. METHODS: We estimated the incidence ...
    • Long term joint consequences of sporting activity: preventing and managing osteoarthritis in the athlete 

      Bennell, Kim L; Hunter, David J.; Vicenzino, Bill (Nature Publishing Group, 2012-07-31)
      Sports participation is associated with an increased risk of future osteoarthritis (OA), much of which results from joint injury. No strong evidence exists that moderate sporting activity in the presence of normal joints ...
    • Management of osteoarthritis of the knee 

      Bennell, Kim L; Hunter, David J.; Hinman, Rana S (British Medical Journal, 2012-07-30)
      Osteoarthritis is a chronic disease; management should be patient centred and coordinated, with attention to modifiable risk factors and comorbidities Focus on conservative non-drug treatment, particularly exercise; for ...
    • The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features 

      Katz, Jeffrey N.; Chaisson, Christine E; Cole, Brian; Guermazi, Ali; Hunter, David J.; Jones, Morgan; Levy, Bruce A; Mandi, Lisa A; Martin, Scott; Marx, Robert G; Safran-Norton, Clare; Roemer, Frank W.; Skoniecki, Debra; Solomon, Daniel H.; Spindler, Kurt P.; Wright, John; Wright, Rick W; Losina, Elena (Elsevier, 2012-11)
      This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled ...
    • Morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis of the knee. 

      Hwang, Seung Hyun; Jung, Kwang-Am; Lee, Won Jun; Yang, Ki Hyuk; Lee, Dong Won; Carter, Aaron; Hunter, David J. (Elsevier, 2012-02)
      OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...
    • Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. 

      Williams, Frances M K; Bansal, Aruna T; van Meurs, Joyce B; Bell, Jordana T; Meulenbelt, Ingrid; Suri, Pradeep; Rivadeneira, Fernando; Sambrook, Philip N; Hofman, Albert; Bierm-Zeinstra, Sita; Menni, Cristina; Kloppenburg, Megreet; Slagboom, P Eline; Hunter, David J.; MacGregor, Alex J; Uitterlinden, Andre G.; Spector, Tim D (BMJ, 2013-07)
      OBJECTIVE: Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. ...
    • Osteoarthritis Preface 

      Hunter, David J. (Elsevier, 2013-02)
      Osteoarthritis (OA) is the leading cause of disability among older adults. It is an incredibly prevalent condition affecting upward of 1 in 8 adults. Societal trends in aging, obesity, and increasing joint injury will lead ...
    • Osteoarthritis: What does imaging tell us about its etiology. 

      Johnson, Victoria L; Giuffre, Bruno M; Hunter, David J. (Thieme Medical Publishers, 2012-11)
      Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. Due to an aging population and increasing obesity, the incidence of OA is rising. The etiology of OA is multifactorial and complex; ...
    • Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review 

      Stordal, Britta; Pavlakis, Nick; Davey, Ross (Elsevier, 2007)
      Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ...