Browsing Research Papers and Publications. NCS Medicine by Title

Now showing items 7-26 of 43

    • EFFECTS OF INTENSIVE DIET AND EXERCISE ON KNEE JOINT LOADS, INFLAMMATION, AND CLINICAL OUTCOMES AMONG OVERWEIGHT AND OBESE ADULTS WITH KNEE OSTEOARTHRITIS 

      Messier, Stephen P; Mihalko, Shannon L; Legault, Claudine; Miller, Gary D.; Nicklas, Barbara J.; DeVita, Paul; Beavers, Daniel P; Hunter, David J.; Lyles, Mary F.; Eckstein, Felix; Williamson, Jeff D; Carr, J. Jeffery; Guermazi, Ali; Loeser, Richard F. (The Journal of the American Medical Association, 2013)
      Importance Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. Objective To determine whether a ≥10% reduction in body ...

    • ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair 

      Stordal, Britta; Davey, Ross (Springer Berlin / Heidelberg, 2008-06-25)
      Background: The H69CIS200 and H69OX400 cell lines are novel models of low- level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather ...

    • The Health and Structural Consequences of Acute Knee Injuries Involving Rupture of the Anterior Cruciate Ligament 

      Riordan, Edward A; Frobell, Richard B; Roemer, Frank W.; Hunter, David J. (Elsevier, 2013-02)
      Although there is an abundance of literature regarding the development of knee osteoarthritis after rupture of the anterior cruciate ligament (ACL), the mechanism underlying this link is not clear. Recent studies have ...

    • Imaging Biomarker Validation and Qualification Report: 6th OARSI Workshop on Imaging in Osteoarthritis Combined with 3rd OA Biomarkers Workshop. 

      Hunter, David J.; Eckstein, Felix; Kraus, Virginia Byers; Lousina, Elena; Sandell, Linda; Guermazi, Ali (Elsevier, 2013-07)
      Summary The sixth Osteoarthritis Research Society International (OARSI) Workshop on Imaging in Osteoarthritis combined with the third osteoarthritis (OA) Biomarkers Workshop is the first to bring together the imaging ...

    • Imaging of Osteoarthritis 

      Guermazi, Ali; Hayashi, Daichi; Eckstein, Felix; Hunter, David J.; Duryea, Jeff; Roemer, Frank W. (Elsevier, 2013-02)
      Osteoarthritis (OA) is the most prevalent joint disorder in the elderly, and there is no effective treatment. Imaging is essential for evaluating the synovial joint structures (including cartilage, meniscus, subchondral ...

    • Lifetime risk and age of diagnosis of symptomatic knee osteoarthritis in the US 

      Losina, Elena; Weinstein, Alexander M.; Reichmann, William M.; Burbine, Sara A.; Solomon, Daniel H.; Daigle, Meghan E.; Rome, Benjamin N.; Chen, Stephanie P.; Hunter, David J.; Suter, Lisa G.; Jordan, Joanne M.; Katz, Jeffrey N. (Willey, 2013-05)
      OBJECTIVE: To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population. METHODS: We estimated the incidence ...

    • Long term joint consequences of sporting activity: preventing and managing osteoarthritis in the athlete 

      Bennell, Kim L; Hunter, David J.; Vicenzino, Bill (Nature Publishing Group, 2012-07-31)
      Sports participation is associated with an increased risk of future osteoarthritis (OA), much of which results from joint injury. No strong evidence exists that moderate sporting activity in the presence of normal joints ...

    • Management of osteoarthritis of the knee 

      Bennell, Kim L; Hunter, David J.; Hinman, Rana S (British Medical Journal, 2012-07-30)
      Osteoarthritis is a chronic disease; management should be patient centred and coordinated, with attention to modifiable risk factors and comorbidities Focus on conservative non-drug treatment, particularly exercise; for ...

    • The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features 

      Katz, Jeffrey N.; Chaisson, Christine E; Cole, Brian; Guermazi, Ali; Hunter, David J.; Jones, Morgan; Levy, Bruce A; Mandi, Lisa A; Martin, Scott; Marx, Robert G; Safran-Norton, Clare; Roemer, Frank W.; Skoniecki, Debra; Solomon, Daniel H.; Spindler, Kurt P.; Wright, John; Wright, Rick W; Losina, Elena (Elsevier, 2012-11)
      This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled ...

    • Morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis of the knee. 

      Hwang, Seung Hyun; Jung, Kwang-Am; Lee, Won Jun; Yang, Ki Hyuk; Lee, Dong Won; Carter, Aaron; Hunter, David J. (Elsevier, 2012-02)
      OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...

    • Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. 

      Williams, Frances M K; Bansal, Aruna T; van Meurs, Joyce B; Bell, Jordana T; Meulenbelt, Ingrid; Suri, Pradeep; Rivadeneira, Fernando; Sambrook, Philip N; Hofman, Albert; Bierm-Zeinstra, Sita; Menni, Cristina; Kloppenburg, Megreet; Slagboom, P Eline; Hunter, David J.; MacGregor, Alex J; Uitterlinden, Andre G.; Spector, Tim D (BMJ, 2013-07)
      OBJECTIVE: Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. ...

    • Osteoarthritis Preface 

      Hunter, David J. (Elsevier, 2013-02)
      Osteoarthritis (OA) is the leading cause of disability among older adults. It is an incredibly prevalent condition affecting upward of 1 in 8 adults. Societal trends in aging, obesity, and increasing joint injury will lead ...

    • Osteoarthritis: What does imaging tell us about its etiology. 

      Johnson, Victoria L; Giuffre, Bruno M; Hunter, David J. (Thieme Medical Publishers, 2012-11)
      Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. Due to an aging population and increasing obesity, the incidence of OA is rising. The etiology of OA is multifactorial and complex; ...

    • Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review 

      Stordal, Britta; Pavlakis, Nick; Davey, Ross (Elsevier, 2007)
      Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ...

    • Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells 

      Stordal, Britta K; Davey, Mary W; Davey, Ross (Springer Verlag, 2006)
      Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ...

    • Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears. 

      Stein, Verena; Li, Ling; Guermazi, Ali; Zhang, Yuqing; Kwoh, C. Kent; Eaton, Charles B; Hunter, David J. (Springer, 2012-02)
      OBJECTIVE: The aim of this study was to evaluate the morphological changes of the lateral meniscus in end-stage lateral compartment osteoarthritis (OA) of the knee. METHODS: One hundred fifty-eight knee joints from 133 ...

    • Presence and Extent of Severe Facet Joint Osteoarthritis Are Associated with Back Pain in Older Adults 

      Suri, Pradeep; Hunter, David J.; Rainville, James; Guermazi, Ali; Katz, Jeffrey N. (Elsevier, 2013-09)
      Objective To determine whether the presence and extent of severe lumbar facet joint osteoarthritis (OA) are associated with back pain in older adults, accounting for disc height narrowing and other covariates. Design Two ...

    • Prevalence of Anatomic Impediments to Interlaminar Lumbar Epidural Steroid Injection 

      Hameed, Farah; Hunter, David J.; Rainville, James; Li, Ling; Suri, Pradeep (Elsevier, 2012-02)
      OBJECTIVE: To determine the prevalence of anatomic impediments to interlaminar lumbar epidural steroid injection (LESI) in a community-based population. DESIGN: Cross-sectional observational study. SETTING: ...

    • Purine-Rich Foods Intake and Recurrent Gout Attacks 

      Zhang, Yuqing; Chen, Clara; Choi, Hyon; Chaisson, Christine E; Hunter, David J.; Niu, Jingbo; Neogi, Tuhina (BMJ, 2012-09)
      OBJECTIVE: To examine and quantify the relation between purine intake and the risk of recurrent gout attacks among gout patients. METHODS: The authors conducted a case-crossover study to examine associations of a set ...

    • Quantification of Walking Ability in Participants with Neurogenic Claudication from Lumbar Spinal Stenosis – A Comparative Study 

      Rainville, James; Childs, Lisa; Pena, Enrique; Suri, Pradeep; Limke, Janet; Jouve, Cristin; Hunter, David J. (Elsevier, 2012-02)
      Background context Walking limitations caused by neurogenic claudication (NC) are typically assessed with self-reported measures, although objective evaluation of walking using motorized treadmill test (MTT) or self-paced ...