|Title:||The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features|
|Authors:||Katz, Jeffrey N.|
Chaisson, Christine E
Hunter, David J.
Levy, Bruce A
Mandi, Lisa A
Marx, Robert G
Roemer, Frank W.
Solomon, Daniel H.
Spindler, Kurt P.
Wright, Rick W
|Citation:||Jeffrey N. Katz, Christine E. Chaisson, Brian Cole, Ali Guermazi, David J. Hunter, Morgan Jones, Bruce A. Levy, Lisa A. Mandl, Scott Martin, Robert G. Marx, Clare Safran-Norton, Frank W. Roemer, Debra Skoniecki, Daniel H. Solomon, Kurt P. Spindler, John Wright, Rick W. Wright, Elena Losina, The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features, Contemporary Clinical Trials, Volume 33, Issue 6, November 2012, Pages 1189-1196|
|Abstract:||This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled trial (RCT) designed to establish the efficacy of arthroscopic partial meniscectomy combined with a standardized physical therapy program as compared with a standardized physical therapy program alone in patients with a symptomatic meniscal tear in the setting of mild to moderate knee osteoarthritic change (OA). The design and execution of a trial that compares surgery with a nonoperative treatment strategy presents distinctive challenges. The goal of this paper is to provide the clinical rationale for MeTeOR and to highlight salient design features, with particular attention to those that present clinical and methodologic challenges.|
|Type of Work:||Article|
|Type of Publication:||Post-print|
|Appears in Collections:||Research Papers and Publications. NCS Medicine|
|36 meteor design paper 011312.pdf||152.92 kB||Adobe PDF|
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