• Acridinone-based anion transporters 

      McNaughton, Daniel A.; Macreadie, Lauren K.; Gale, Philip A.
      Published 2021
      The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea ...
      Open Access
      Article
    • Binding and transport properties of a benzo[b]thiophene-based mono-(thio)urea library 

      Moiteiro, Cristina; Marques, Igor; Ryder, William G.; Cachatra, Vasco; Carvalho, Sílvia; Chen, Li-Jun; Goodfellow, Brian J.; Gale, Philip A.; Félix, Vítor
      Published 2021
      Using the chemical versatility of the benzo[ b ]thiophene motif, an extensive library of 24 (thio)urea receptors, with different binding properties and lipophilicities was prepared and included α,α-, α,β-, β,β-, β,γ-, α,γ-, ...
      Open Access
      Article
    • Carbazole-based bis-ureas and thioureas as electroneutral anion transporters 

      Wang, Patrick; Wu, Xin; Gale, Philip A.
      Published 2021
      We report a series of easily accessible carbazole-based bis-ureas and thioureas as effective anion receptors and transporters. The compounds exhibit moderate Cl− binding affinity in wet DMSO and Cl− transport capabilities ...
      Open Access
      Article
    • Crown ether-thiourea conjugates as ion transporters 

      Zhao, Zhixing; Tang, Bailing; Yan, Xiaosheng; Wu, Xin; Li, Zhao; Gale, Philip A.; Jiang, Yun-Bao
      Published 2022
      Na+, Cl− and K+ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic ...
      Open Access
      Article
    • Delivering anion transporters to lipid bilayers in water 

      McNaughton, Daniel A.; To, Tsz Ying (Teresa); Hawkins, Bryson A.; Hibbs, David E.; Gale, Philip A.
      Published 2021
      Cyclodextrins have been employed as delivery agents for lipophilic anion transporters, which allow their incorporation into lipid bilayers without using an organic solvent or pre-incorporation.
      Open Access
      Article
    • E_File_8 - Chapter 4 DFT optimised coordinates.zip 

      Canfield, Peter John
      Published 2018
      Zip archive folder of all Density-Functional Theory optimised molecular structures (Cartesian coordinates) reported in Thesis Chapter 4.
      Open Access
      Dataset
    • Halide-selective, proton-coupled anion transport by phenylthiosemicarbazones 

      Howe, Ethan N.W.; Chang, Vai-Vai Tiffany; Wu, Xin; Fares, Mohamed; Lewis, William; Macreadie, Lauren K.; Gale, Philip A.
      Published 2022
      Phenylthiosemicarbazones (PTSCs) are proton-coupled anion transporters with pH-switchable behaviour known to be regulated by an imine protonation equilibrium. Previously, chloride/nitrate exchange by PTSCs was found to be ...
      Embargoed
      Article
    • Measuring anion transport selectivity: a cautionary tale 

      Wu, Xin; Gale, Philip A.
      Published 2021
      pH-dependent liposomal assays are often used to determine anion selectivity in transmembrane anion transport experiments. We discuss the validity and limitations of these assays, and provide guidelines for their use to ...
      Open Access
      Article
    • Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas 

      Wezenberg, Sander J.; Chen, Li-Jun; Howe, Ethan N.W.; Wu, Xin; Siegler, Maxime A.; Gale, Philip A.; Bos, Jasper E.; Feringa, Ben L.
      Published 2021
      Membrane transport proteins fulfil important regulatory functions in biology with a common trait being their ability to respond to stimuli in the environment. Various small-molecule receptors, capable of mediating transmembrane ...
      Open Access
      Article
    • Progress in Anion Receptor Chemistry 

      Macreadie, lauren K.; Gilchrist, Alexander M.; McNaughton, Daniel A.; Ryder, William G.; Fares, Mohamed; Gale, Philip A.
      Published 2022
      This review covers advances made in anion complexation in the years 2019 and 2020. Included here are developments in self-assembly, sensing, anion separation, transport, catalysis, and fundamental advances in anion recognition ...
      Embargoed
      Article
    • Synthetic Na+/K+ exchangers promote apoptosis by disturbing cellular cation homeostasis 

      Park, Sang-Hyun; Hwang, Inhong; McNaughton, Daniel A.; Kinross, Airlie J.; Howe, Ethan N.W.; Xiong, Shenglun; Kilde, Martin Drøhse; Lynch, Vincent M.; Gale, Philip A.; Sessler, Jonathan L.; Shin, Injae; He, Qing
      Published 2021
      A number of artificial cation ionophores (or transporters) have been developed for basic research and biomedical applications. However, their mechanisms of action and the putative correlations between changes in intracellular ...
      Open Access
      Article
    • A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment 

      Chen, Li-Jun; Humphrey, Sean; Zhu, Jun-Long; Zhu, Fan-Fan; Wang, Xu-Qing; Wang, Xiang; Wen, Jin; Yang, Hai-Bo; Gale, Philip A.
      Published 2021
      The selective and efficient capture of phosphopeptides is critical for comprehensive and in-depth phosphoproteome analysis. Reported here is a new switchable two-dimensional (2D) supramolecular polymer that can serve as ...
      Open Access
      Article