School of Chemistry: Recent submissions
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Acridinone-based anion transporters
Published 2021The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea ...Open AccessArticle -
Halide-selective, proton-coupled anion transport by phenylthiosemicarbazones
Published 2022Phenylthiosemicarbazones (PTSCs) are proton-coupled anion transporters with pH-switchable behaviour known to be regulated by an imine protonation equilibrium. Previously, chloride/nitrate exchange by PTSCs was found to be ...Open AccessArticle -
Synthesis, X-ray crystallographic analysis, DFT studies and biological evaluation of triazolopyrimidines and 2-anilinopyrimidines
Published 2022Inspired by the reported antiviral activity of pyrimidines and triazolopyrimidines, two series of 2-anilinopyrimidines (5a-e) and 1-aryl-[1,2,4]triazolo[4,3-a]pyrimidines (14a-k) were designed and synthesized as potential ...Open AccessArticle -
Measuring anion transport selectivity: a cautionary tale
Published 2021pH-dependent liposomal assays are often used to determine anion selectivity in transmembrane anion transport experiments. We discuss the validity and limitations of these assays, and provide guidelines for their use to ...Open AccessArticle -
A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment
Published 2021The selective and efficient capture of phosphopeptides is critical for comprehensive and in-depth phosphoproteome analysis. Reported here is a new switchable two-dimensional (2D) supramolecular polymer that can serve as ...Open AccessArticle