Stimuli-responsive cycloaurated ‘OFF-ON’ switchable anion transporters
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Open Access
Type
ArticleAuthor/s
Fares, MohamedWu, Xin
Ramesh, Deepthi
Lewis, William
Keller, Paul A.
Howe, Ethan N.W.
Pérez-Tomás, Ricardo
Gale, Philip A.
Abstract
Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are ‘switched on’ in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumours than in healthy tissue and hence this approach offers a strategy to target these systems to tumours.Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are ‘switched on’ in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumours than in healthy tissue and hence this approach offers a strategy to target these systems to tumours.
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Date
2020-01-01Source title
Angewandte Chemie International EditionVolume
59Publisher
Wiley-VCH GmbHFunding information
ARC DP200100453Licence
Copyright All Rights ReservedRights statement
"This is the peer reviewed version of the following articleM. Fares, X. Wu, D. Ramesh, W. Lewis, P. A. Keller, E. N. W. Howe, R. Pérez-Tomás, P. A. Gale, Angew. Chem. Int. Ed. 2020, 59, 17614,,which has been published in final form at https://doi.org/10.1002/anie.202006392.This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Faculty/School
Faculty of Science, School of ChemistryShare