High mitochondrial accumulation of new gadolinium(III) agents within tumour cells

Morrison, Daniel E.; Aitken, Jade B.; de Jonge, Martin D.; Ioppolo, Joseph A.; Harris, Hugh H.; Rendina, Louis M.

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Open Access

Field	Value	Language
dc.contributor.author	Morrison, Daniel E.
dc.contributor.author	Aitken, Jade B.
dc.contributor.author	de Jonge, Martin D.
dc.contributor.author	Ioppolo, Joseph A.
dc.contributor.author	Harris, Hugh H.
dc.contributor.author	Rendina, Louis M.
dc.date.accessioned	2019-12-20
dc.date.available	2019-12-20
dc.date.issued	2014-01-01
dc.identifier.citation	Chem. Commun., 2014, 50, 2252-2254	en
dc.identifier.uri	https://hdl.handle.net/2123/21596
dc.description.abstract	The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10^10 Gd atoms per tumour cell.	en
dc.description.sponsorship	Australian Research Council (ARC)	en
dc.language.iso	en	en
dc.publisher	Royal Society of Chemistry	en
dc.relation	ARC	en
dc.rights	Other	en
dc.subject	cancer	en
dc.subject	neutron capture therapy	en
dc.subject	photon activated therapy	en
dc.subject	gadolinium	en
dc.title	High mitochondrial accumulation of new gadolinium(III) agents within tumour cells	en
dc.type	Article	en
dc.subject.asrc	FoR::030201 - Bioinorganic Chemistry	en
dc.subject.asrc	FoR::030202 - f-Block Chemistry	en
dc.subject.asrc	FoR::030299 - Inorganic Chemistry not elsewhere classified	en
dc.subject.asrc	FoR::111207 - Molecular Targets	en
dc.subject.asrc	FoR::111204 - Cancer Therapy (excl. Chemotherapy and Radiation Therapy)	en
dc.identifier.doi	10.1039/c3cc46903d
dc.type.pubtype	Author accepted manuscript	en
usyd.faculty	Faculty of Science, School of Chemistry