High mitochondrial accumulation of new gadolinium(III) agents within tumour cells
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Open Access
Type
ArticleAuthor/s
Morrison, Daniel E.Aitken, Jade B.
de Jonge, Martin D.
Ioppolo, Joseph A.
Harris, Hugh H.
Rendina, Louis M.
Abstract
The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10^10 Gd atoms per tumour cell.The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10^10 Gd atoms per tumour cell.
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Date
2014-01-01Publisher
Royal Society of ChemistryLicence
OtherFaculty/School
Faculty of Science, School of ChemistryCitation
Chem. Commun., 2014, 50, 2252-2254Share