Research Publications and Outputs: Recent submissions
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Voltage-Switchable HCl Transport Enabled by Lipid Headgroup–Transporter Interactions
Published 2019-08-30Synthetic anion transporters that facilitate transmembrane H+/Cl- symport (cotransport) have anti-cancer potential due to their ability to neutralize pH gradients and inhibit autophagy in cells. However, compared to the ...Open AccessArticle -
Fatty Acid Fueled Transmembrane Chloride Transport
Published 2019-06-21Generation of chemical gradients across biological membranes of cellular compartments is a hallmark of all living systems. Here we report a proof-of-concept prototype transmembrane pumping system in liposomes. The pump ...Open AccessArticle -
Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs†
Published 2019-10-01Defective anion transport is a hallmark of the genetic disease cystic fibrosis (CF). One approach to restore anion transport to CF cells utilises alternative pathways for transmembrane anion transport, including artificial ...Open AccessArticle -
Effect of cholesterol on the dipole potential of lipid membranes
Published 2019-01-01The membrane dipole potential, ψd, is an electrical potential difference with a value typically in the range 150 – 350 mV (positive in the membrane interior) which is located in the lipid headgroup region of the membrane, ...Open AccessBook chapter -
New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas
Published 2018-06-19The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism ...Open AccessArticle