Browsing by author "Howe, Ethan N.W."
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Advances in Anion Receptor Chemistry
Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.Published 2020-01-01This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...Open AccessArticle -
Anion receptor chemistry: Highlights from 2016
Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J.Published 2018-02-01This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.Open AccessArticle -
Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate
Ariawan, A. Daryl; Webb, James E.A.; Howe, Ethan N.W.; Gale, Philip A.; Thordarson, Pall; Hunter, LukePublished 2017-02-01Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...Open AccessArticle -
Development of a library of thiophene-based drug-like LEGO molecules: evaluation of their anion binding, transport properties and cytotoxicity
Vieira, Paulo; Miranda, Margarida Q.; Marques, Igor; Carvalho, Sílvia; Li-Jun, Chen; Howe, Ethan N.W.; Zhen, Carl; Leung, Claudia Y.; Spooner, Michael J.; Morgado, Bárbara; da Cruz e Silva, Odete A.B.; Moiteiro, Cristina; Gale, Philip A.; Félix, VítorPublished 2020-01-01The anion binding and transport properties of an extensive library of thiophene-based molecules are reported. Seventeen bis-urea positional isomers, with different binding conformations and lipophilicities, were synthetized ...Open AccessArticle -
Fatty Acid Fueled Transmembrane Chloride Transport
Howe, Ethan N.W.; Gale, Philip A.Published 2019-06-21Generation of chemical gradients across biological membranes of cellular compartments is a hallmark of all living systems. Here we report a proof-of-concept prototype transmembrane pumping system in liposomes. The pump ...Open AccessArticle -
Fluorescent squaramides as anion receptors and transmembrane anion transporters
Bao, Xiaoping; Wu, Xin; Berry, Stuart N.; Howe, Ethan N.W.; Chang, Young-Tae; Gale, Philip A.Published 2018-01-01A series of squaramide-based anion transporters functionalised with the 1,8-naphthalimide fluorophore has been developed for improved ionophoric activity and fluorescent imaging in cells.Open AccessArticle -
Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport
Spooner, Michael J.; Li, Hongyu; Marques, Igor; Costa, Pedro M.R.; Wu, Xin; Howe, Ethan N.W.; Busschaert, Nathalie; Moore, Stephen J.; Light, Mark E.; Sheppard, David N.; Gale, Philip A.Published 2018-01-01A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate their mechanism of action using anion transport assays in cells ...Open AccessArticle -
Fluorinated tripodal receptors for potentiometric chloride detection in biological fluids
Pankratova, Nadezda; Cuartero, Maria; Jowett, Laura A.; Howe, Ethan N.W.; Gale, Philip A.; Bakker, Eric; Crespo, Gastón A.Published 2017-07-01Fluorinated tripodal compounds were recently reported to be efficient transmembrane transporters for a series of inorganic anions. In particular, this class of receptors has been shown to be suitable for the effective ...Open AccessArticle -
Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations
Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, VítorPublished 2018-01-01A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...Open AccessArticle -
Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations
Marques, Igor; Costa, Pedro M.R.; Miranda, Margarida Q.; Busschaert, Nathalie; Howe, Ethan N.W.; Clarke, Harriet J.; Haynes, Cally J.E.; Kirby, Isabelle L.; Rodilla, Ananda M.; Pérez-Tomás, Ricardo; Gale, Philip A.; Félix, VítorPublished 2018-06-29A comprehensive experimental and theoretical investigation of the transmembrane chloride transport promoted by four series of squaramide derivatives, with different degrees of fluorination, number of convergent N–H binding ...Open AccessArticle -
Halide-selective, proton-coupled anion transport by phenylthiosemicarbazones
Howe, Ethan N.W.; Chang, Vai-Vai Tiffany; Wu, Xin; Fares, Mohamed; Lewis, William; Macreadie, Lauren K.; Gale, Philip A.Published 2022Phenylthiosemicarbazones (PTSCs) are proton-coupled anion transporters with pH-switchable behaviour known to be regulated by an imine protonation equilibrium. Previously, chloride/nitrate exchange by PTSCs was found to be ...Open AccessArticle -
Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents
Jowett, Laura A.; Howe, Ethan N.W.; Soto-Cerrato, Vanessa; Van Rossom, Wim; Pérez-Tomás, Ricardo; Gale, Philip A.Published 2017-01-01Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H+/Cl− ...Open AccessArticle -
Investigating the Influence of Steric Hindrance on Selective Anion Transport
Jowett, Laura A.; Ricci, Angela; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.Published 2019-04-02A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied. Overall, increasing the steric bulk of the substituents ...Open AccessArticle -
New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas
Jowett, Laura A.; Howe, Ethan N.W.; Wu, Xin; Busschaert, Nathalie; Gale, Philip A.Published 2018-06-19The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism ...Open AccessArticle -
Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas
Wezenberg, Sander J.; Chen, Li-Jun; Howe, Ethan N.W.; Wu, Xin; Siegler, Maxime A.; Gale, Philip A.; Bos, Jasper E.; Feringa, Ben L.Published 2021Membrane transport proteins fulfil important regulatory functions in biology with a common trait being their ability to respond to stimuli in the environment. Various small-molecule receptors, capable of mediating transmembrane ...Open AccessArticle -
Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux
Zhang, Shaoyi; Wang, Yan; Xie, Wei; Howe, Ethan N.W.; Busschaert, Nathalie; Sauvat, Allan; Leduc, Marion; Gomes-da-Silva, Ligia C.; Chen, Guo; Martins, Isabelle; Deng, Xiaxing; Maiuri, Luigi; Kepp, Oliver; Soussi, Thierry; Gale, Philip A.; Zamzami, Naoufal; Kroemer, GuidoPublished 2019-02-01Cystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate ...Open AccessArticle -
Stimuli-responsive cycloaurated ‘OFF-ON’ switchable anion transporters
Fares, Mohamed; Wu, Xin; Ramesh, Deepthi; Lewis, William; Keller, Paul A.; Howe, Ethan N.W.; Pérez-Tomás, Ricardo; Gale, Philip A.Published 2020-01-01Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes ...Open AccessArticle -
Supramolecular transmembrane anion transport: new assays and insights
Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.Published 2018Transmembrane anion transport has been the focus of a number of supramolecular chemistry research groups for a number of years. Much of this research is driven by the biological relevance of anion transport and the search ...Open AccessArticle -
Synthetic Na+/K+ exchangers promote apoptosis by disturbing cellular cation homeostasis
Park, Sang-Hyun; Hwang, Inhong; McNaughton, Daniel A.; Kinross, Airlie J.; Howe, Ethan N.W.; Xiong, Shenglun; Kilde, Martin Drøhse; Lynch, Vincent M.; Gale, Philip A.; Sessler, Jonathan L.; Shin, Injae; He, QingPublished 2021A number of artificial cation ionophores (or transporters) have been developed for basic research and biomedical applications. However, their mechanisms of action and the putative correlations between changes in intracellular ...Open AccessArticle -
Tetrapodal Anion Transporters
Gilchrist, Alexander M.; Chen, Lijun; Wu, Xin; Lewis, William; Howe, Ethan N.W.; Macreadie, Lauren K.; Gale, Philip A.Published 2020-01-01Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via ...Open AccessArticle
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