School of Medical Sciences: Recent submissions
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PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9
Published 2012-02-01The mesenchymal mode of cancer cell invasion characterized by active adhesion turnover and a polarized actin cytoskeleton, is critically regulated by the adaptor protein NEDD9/HEF1/Cas-L. While it is known that NEDD9 is ...Open AccessArticle -
2-methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death.
Published 2015-04-15CASE REPORT: We report a fatal case of a 37 year old gentleman who ingested a MCPA/bromoxynil co-formulation herbicide. Although clinically well on initial examination, our patient declined dramatically over his 18 h ...Open AccessArticle -
A decade of Australian methotrexate dosing errors
Published 2016-06-06"OBJECTIVE: Accidental daily dosing of methotrexate can result in life-threatening toxicity. We investigated methotrexate dosing errors reported to the National Coronial Information System (NCIS), the Therapeutic Goods ...Open AccessArticle -
Tropomyosin Tm5NM1 spatially restricts src kinase activity through perturbation of Rab11 vesicle trafficking
Published 2014-12-01In order for cells to stop moving, they must synchronously stabilize actin filaments and their associated focal adhesions. How these two structures are coordinated in time and space is not known. We show here that the actin ...Open AccessArticle -
Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism
Published 2012-10-24Long-term glucocorticoid treatment is associated with numerous adverse outcomes, including weight gain, insulin resistance, and diabetes; however, the pathogenesis of these side effects remains obscure. Glucocorticoids ...Open AccessArticle