School of Medical Sciences

 

Sub-collections in this collection

Recent Submissions

  • Erratum for Zhao et al., "Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1". 

    Zhao, Kaitao; Ke, Zunhui; Hu, Hongbing; Liu, Yahui; Li, Aixin; Hua, Rong; Guo, Fangteng; Xiao, Junfeng; Zhang, Yu; Duan, Ling; Yan, Xin-Fu; Gao, Yong-Gui; Liu, Bing; Xia, Yuchen; Li, Yan
    Published 2021
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  • Vaccine nationalism and the dynamics and control of SARS-CoV-2 

    Wagner, Caroline E.; Saad-Roy, Chadi M.; Morris, Sinead E.; Baker, Rachel E.; Mina, Michael J.; Farrar, Jeremy; Holmes, Edward C.; Pybus, Oliver G.; Graham, Andrea L.; Emanuel, Ezekiel J.; Levin, Simon A.; Metcalf, C. Jessica E.; Grenfell, Bryan T.
    Published 2021
    Vaccines provide powerful tools to mitigate the enormous public health and economic costs that the ongoing SARS-CoV-2 pandemic continues to exert globally, yet vaccine distribution remains unequal between countries. To ...
    Preprint
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  • Sequence dynamics of three influenza A virus strains grown in different MDCK cell lines, including those expressing different sialic acid receptors 

    Barnard, Karen N.; Wasik, Brian R.; Alford, Brynn K.; Hayward, Jessica J.; Weichert, Wendy S.; Voorhees, Ian E. H.; Holmes, Edward C.; Parrish, Colin R.
    Published 2021
    Viruses are often cultured in cell lines for research and vaccine development, and those often differ from the natural hosts or tissues. Cell lines can also differ in the presence of virus receptors, such as the sialic ...
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  • The role of gene segment interactions in driving the emergence of dominant gene constellations during influenza virus reassortment 

    Trifkovic, Sanja; Gilbertson, Brad; Fairmaid, Emily; Cobbin, Joanna; Rockman, Steven; Brown, Lorena E.
    Published 2021
    Abstract A segmented genome enables influenza virus to undergo reassortment when two viruses infect the same cell. Resulting reassorted progeny have a spectrum of gene constellations and potentially different phenotypes. ...
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  • Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity 

    Zhang, Wuji; Chua, Brendon Y.; Selva, Kevin J.; Kedzierski, Lukasz; Ashhurst, Thomas M.; Haycroft, Ebene R.; Shoffner, Suzanne K.; Hensen, Luca; Boyd, David F.; James, Fiona; Mouhtouris, Effie; Kwong, Jason C.; Chua, Kyra Y. L.; Drewett, George; Copaescu, Ana; Dobson, Julie E.; Rowntree, Louise C.; Habel, Jennifer R.; Allen, Lilith F.; Koay, Hui-Fern; Neil, Jessica A.; Gartner, Matthew; Lee, Christina Y.; Andersson, Patiyan; Seemann, Torsten; Sherry, Norelle L.; Amanat, Fatima; Krammer, Florian; Londrigan, Sarah L.; Wakim, Linda M.; King, Nicholas J.C.; Godfrey, Dale I.; Mackay, Laura K.; Thomas, Paul G.; Nicholson, Suellen; Arnold, Kelly B.; Chung, Amy W.; Holmes, Natasha E.; Smibert, Olivia C.; Trubiano, Jason A.; Gordon, Claire L.; Nguyen, Thi H.O.; Kedzierska, Katherine
    Published 2021
    ABSTRACT Although the respiratory tract is the primary site of SARS-CoV-2 infection and the ensuing immunopathology, respiratory immune responses are understudied and urgently needed to understand mechanisms underlying ...
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