Browsing School of Medical Sciences by title
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[18F]AV-1451 PET in behavioural variant frontotemporal dementia due to MAPT mutation
Published 2016-10-18The validation of tau radioligands could improve the diagnosis of frontotemporal lobar degeneration and the assessment of disease-modifying therapies. Here, we demonstrate that binding of the tau radioligand [18F]AV-1451 ...Open AccessArticle -
2-methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death.
Published 2015-04-15CASE REPORT: We report a fatal case of a 37 year old gentleman who ingested a MCPA/bromoxynil co-formulation herbicide. Although clinically well on initial examination, our patient declined dramatically over his 18 h ...Open AccessArticle -
3-dimensional NET image
Published 2021-03-29Z stacking of human Crohn's disease ileum specimen labelling neutrophil extracellular traps (NETs) structures including DNA, citrinillated H3, DNA, myeloperoxidase and neutrophil elastase. Image was labelled using a modified ...Open AccessAudiovisual -
Acute alcohol co-ingestion and hospital-treated deliberate self-poisoning; is there an effect on subsequent self-harm?
Published 2018-03-01The aim of this study was to determine the relationship between alcohol co-ingestion in an index deliberate self-poisoning (DSP) episode with repeated DSP and subsequent suicide. A retrospective cohort study was conducted ...Open AccessArticle -
Adding a diazo-transfer reagent to culture to generate secondary metabolite probes for click chemistry
Published 2022Converting discrete microbial metabolites into chemical probes for chemical biology and medicinal chemistry studies is typically preceded by lengthy purification and chemical derivatization processes. Standard practice ...Book chapter -
After the pandemic: perspectives on the future trajectory of COVID-19. [Review]
Published 2021There is a realistic expectation that the global effort in vaccination will bring the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic under control. Nonetheless, uncertainties remain about the type ...Article -
Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult.
Published 2015-09-01In a series of neurophysiological and neuroimaging studies we investigated the neurobiology related to alcohol use in young people with bipolar disorder. Impairments were identified across frontal and temporal representations ...Open AccessArticle -
Alternatives to Student Outbound Mobility-Improving Students' Cultural Competency Skills Online to Improve Global Health Without Travel.
Published 2021Introduction Student outbound mobility is a major element in internationalization of medical education and global health education. However, this approach is often criticized, as it is inherently inequitable. Internationalization ...Article -
Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
Published 2022Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (Mpro) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. Here we ...Article -
Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients
Published 2013-02-28Background The risk of cytomegalovirus (CMV) infection in solid organ transplant recipients has resulted in the frequent use of prophylaxis with the aim of preventing the clinical syndrome associated with CMV infection. ...Open AccessArticle -
Antiviral Medications for Preventing Cytomegalovirus Disease in Solid Organ Transplant Recipients
Published 2005-10-19Background: The risk of cytomegalovirus (CMV) infection in solid organ transplant recipients has resulted in the frequent use of prophylaxis with the aim of preventing the clinical syndrome associated with CMV infection. ...Open AccessArticle -
Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes
Published 2017-05-29The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on the prevalence and severity of Aβ ...Open AccessArticle -
Assessment of Coronavirus Disease 2019 Intervention Strategies in the Nordic Countries Using Genomic Epidemiology
Published 2022We explored how the duration, size, and number of virus transmission clusters, defined as country-specific monophyletic groups in a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) phylogenetic tree, differed ...Article -
Azido-Desferrioxamine Siderophores as Functional Click-Chemistry Probes Generated in Culture upon Adding a Diazo-Transfer Reagent
Published 2020This work aimed to undertake the in situ conversion of the terminal amine groups of bacterial desferrioxamine (DFO) siderophores, including desferrioxamine B (DFOB), to azide groups to enable downstream click chemistry. ...Open AccessPre-print -
Barriers to the Professional Advancement of Women in Nephrology
Published 2019-07-26Open AccessArticle -
Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) poisoning could be a bad combination
Published 2018-01-30Open AccessArticle, Letter -
Challenges for Opioid Receptor Nomenclature
Published 2015-01-01Recent developments in the study of the structure and function of opioid receptors raise significant challenges for the definition of individual receptor types and the development of a nomenclature that precisely describes ...Open AccessArticle -
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
Published 2012-06-01The human neuroblastoma cell line SH-SY5Y is a potentially useful model for the identification and characterisation of Na(v) modulators, but little is known about the pharmacology of their endogenously expressed Na(v)s. ...Open AccessArticle -
Chronic morphine reduces surface expression of δ-opioid receptors in subregions of rostral striatum
Published 2015-04-13The delta opioid receptor (DOPr), whilst not the primary target of clinically used opioids, is involved in development of opioid tolerance and addiction. There is growing evidence that DOPr trafficking is involved in drug ...Open AccessArticle