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Publication year 2020 - 2023 (4)2010 - 2019 (33)2006 - 2009 (10)Type Article (40)Book chapter (2)Conference poster (1)Dataset (1)Other (1)Preprint (1)Authors Hunter, David J. (34)Guermazi, Ali (13)Davey, Ross (7)Eckstein, Felix (7)Katz, Jeffrey N. (7)Stordal, Britta (7)Suri, Pradeep (7)Li, Ling (6)Rainville, James (6)Bennell, Kim L (4)View moreSubjects 110322 - Rheumatology and Arthritis (33)Osteoarthritis (25)Cisplatin (6)Resistance (5)Oxaliplatin (4)Paclitaxel (3)06 Biological Sciences (2)0803 Computer Software (2)0806 Information Systems (2)11 Medical and Health Sciences (2)View moreHas file(s)
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THE RELATIONSHIP OF TIBIAL BONE PERFUSION TO PAIN IN KNEE OSTEOARTHRITIS. 

Seah, S; Wheaton, D; Li, Ling; Dyke, J P; Talmo, C; Harvey, William F; Hunter, David J.
Published 2012-12-01
Objective To confirm altered perfusion within tibial bone marrow lesions (BMLs) and improve our understanding on the relationship between BMLs and pain in knee osteoarthritis (OA). Methods Participants with moderate to ...
Open Access
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The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features 

Katz, Jeffrey N.; Chaisson, Christine E; Cole, Brian; Guermazi, Ali; Hunter, David J.; Jones, Morgan; Levy, Bruce A; Mandi, Lisa A; Martin, Scott; Marx, Robert G; Safran-Norton, Clare; Roemer, Frank W.; Skoniecki, Debra; Solomon, Daniel H.; Spindler, Kurt P.; Wright, John; Wright, Rick W; Losina, Elena
Published 2012-11-01
This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled ...
Open Access
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ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair 

Stordal, Britta; Davey, Ross
Published 2008-06-25
Background: The H69CIS200 and H69OX400 cell lines are novel models of low- level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the ...
Open Access
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Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells 

Stordal, Britta K; Davey, Mary W; Davey, Ross
Published 2006-01-01
Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ...
Open Access
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Understanding cisplatin resistance using cellular models 

Stordal, Britta; Davey, Mary W
Published 2007-01-01
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of ...
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A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship 

Stordal, Britta; Pavlakis, Nick; Davey, Ross
Published 2007-01-01
We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for 1) cell models of acquired drug ...
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Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review 

Stordal, Britta; Pavlakis, Nick; Davey, Ross
Published 2007-01-01
Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ...
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Regrowth resistance: low-level platinum resistance mediated by rapid recovery from platinum-induced cell-cycle arrest 

Stordal, Britta; Davey, Ross
Published 2009-01-01
The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum drug resistance developed from H69 human small-cell lung cancer cells with eight 4-day treatments of 200 ng/ml cisplatin and 400 ng/ml oxaliplatin, ...
Open Access
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Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy. 

Stordal, Britta; Pavlakis, Nick; Davey, Ross
Published 2009-01-01
Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer. Methods: Medline was searched for 1) Cell models of ...
Open Access
Book chapter
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EFFECTS OF INTENSIVE DIET AND EXERCISE ON KNEE JOINT LOADS, INFLAMMATION, AND CLINICAL OUTCOMES AMONG OVERWEIGHT AND OBESE ADULTS WITH KNEE OSTEOARTHRITIS 

Messier, Stephen P; Mihalko, Shannon L; Legault, Claudine; Miller, Gary D.; Nicklas, Barbara J.; DeVita, Paul; Beavers, Daniel P; Hunter, David J.; Lyles, Mary F.; Eckstein, Felix; Williamson, Jeff D; Carr, J. Jeffery; Guermazi, Ali; Loeser, Richard F.
Published 2013-01-01
Importance Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. Objective To determine whether a ≥10% reduction in body weight ...
Open Access
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