Selective delivery of remarkably high levels of gadolinium to tumour cells using an arsonium salt
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Open Access
Type
ArticleAuthor/s
Windsor, Madeline S. A.Busse, Madleen
Morrison, Daniel E.
Baker, Robert W.
Hill, Leila R.
Rendina, Louis M.
Abstract
The use of a triphenylarsonium vector for tumour cell-targeting leads to a dramatic increase in Gd3+ uptake in human glioblastoma multiforme cells by up to an order of magnitude over the isosteric triarylphosphonium analogue, with significant implications for ‘theranostic’ applications involving delivery of this important lanthanoid metal ion to tumour cells.The use of a triphenylarsonium vector for tumour cell-targeting leads to a dramatic increase in Gd3+ uptake in human glioblastoma multiforme cells by up to an order of magnitude over the isosteric triarylphosphonium analogue, with significant implications for ‘theranostic’ applications involving delivery of this important lanthanoid metal ion to tumour cells.
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Date
2021Source title
Chemical CommunicationsVolume
57Publisher
Royal Society of ChemistryFunding information
ARC DP190103461Licence
Copyright All Rights ReservedFaculty/School
Faculty of Science, School of ChemistryShare