Unlocking therapeutic potential: the role of adamantane in drug discovery
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Open Access
Type
ArticleAuthor/s
Dane, ChiannaCumbers, Grace A.
Allen, Beau
Montgomery, Andrew P.
Danon, Jonathan J.
Kassiou, Michael
Abstract
The unique structural and physicochemical properties of adamantane and its derivatives have attracted considerable attention in the field of medicinal chemistry. Substituting phenyl rings for adamantane or its derivatives has provided a promising strategy to introduce lipophilicity ...
See moreThe unique structural and physicochemical properties of adamantane and its derivatives have attracted considerable attention in the field of medicinal chemistry. Substituting phenyl rings for adamantane or its derivatives has provided a promising strategy to introduce lipophilicity and escape the ‘flat land’ of modern drug discovery. Additionally, the unique three-dimensional structure of adamantane facilitates the precise positioning of substituents allowing for a more effective exploration of drug targets. Evidently, we have seen an increased use of adamantane in pharmaceutically relevant molecules. The following Account highlights our group’s research in five drug discovery programs over the past 15 years showcasing the use of adamantane and its analogues in these studies.
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See moreThe unique structural and physicochemical properties of adamantane and its derivatives have attracted considerable attention in the field of medicinal chemistry. Substituting phenyl rings for adamantane or its derivatives has provided a promising strategy to introduce lipophilicity and escape the ‘flat land’ of modern drug discovery. Additionally, the unique three-dimensional structure of adamantane facilitates the precise positioning of substituents allowing for a more effective exploration of drug targets. Evidently, we have seen an increased use of adamantane in pharmaceutically relevant molecules. The following Account highlights our group’s research in five drug discovery programs over the past 15 years showcasing the use of adamantane and its analogues in these studies.
See less
Date
2024Source title
Australian Journal of ChemistryVolume
77Issue
8Publisher
CSIRO PublishingFunding information
The work presented herein was supported by the Australian Research Council and the National Health and Medical Research Council.
Licence
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0Rights statement
© 2024 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)Faculty/School
Faculty of Science, School of ChemistryShare