Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET
Type
Conference paperAuthor/s
Visser, DeniseGolla, Sandeep S.V.
Verfaillie, Sander C.J.
Coomans, Emma M.
Rikken, Roos M.
van de Giessen, Elsmarieke M.
Hollander, Marijke E. den
Verveen, Anouk
Yaqub, Maqsood
Barkhof, Frederik
Horn, Janneke
Koopman, Bart
Schober, Patrick
Koch, Dook W.
Schuit, Robert C.
Windhorst, Albert D.
Kassiou, Michael
Boellaard, Ronald
van Vugt, Michele
Knoop, Hans
Tolboom, Nelleke
van Berckel, Bart N.M.
Abstract
Summary A significant number of COVID-19 patients develop ‘long COVID’, a condition defined by long-lasting debilitating, often neurological, symptoms. The pathophysiology of long COVID is unknown. Here we present in-vivo evidence of widespread neuroinflammation in long COVID, ...
See moreSummary A significant number of COVID-19 patients develop ‘long COVID’, a condition defined by long-lasting debilitating, often neurological, symptoms. The pathophysiology of long COVID is unknown. Here we present in-vivo evidence of widespread neuroinflammation in long COVID, using a quantitative assessment, [ 18 F]DPA-714 PET, in two long COVID patients. We reanalyzed historical data from three matched healthy control subjects, for comparison purposes. Both patients with long COVID had widespread increases in [ 18 F]DPA-714 binding throughout the brain. Quantitative measures of binding (BP ND values) were increased on average by 121% and 76%, respectively. This implicates profound neuroinflammation in the pathophysiology of long COVID.
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See moreSummary A significant number of COVID-19 patients develop ‘long COVID’, a condition defined by long-lasting debilitating, often neurological, symptoms. The pathophysiology of long COVID is unknown. Here we present in-vivo evidence of widespread neuroinflammation in long COVID, using a quantitative assessment, [ 18 F]DPA-714 PET, in two long COVID patients. We reanalyzed historical data from three matched healthy control subjects, for comparison purposes. Both patients with long COVID had widespread increases in [ 18 F]DPA-714 binding throughout the brain. Quantitative measures of binding (BP ND values) were increased on average by 121% and 76%, respectively. This implicates profound neuroinflammation in the pathophysiology of long COVID.
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Date
2022Licence
OtherFaculty/School
Faculty of Science, School of ChemistryShare