Crown ether-thiourea conjugates as ion transporters
Field | Value | Language |
dc.contributor.author | Zhao, Zhixing | |
dc.contributor.author | Tang, Bailing | |
dc.contributor.author | Yan, Xiaosheng | |
dc.contributor.author | Wu, Xin | |
dc.contributor.author | Li, Zhao | |
dc.contributor.author | Gale, Philip A. | |
dc.contributor.author | Jiang, Yun-Bao | |
dc.date.accessioned | 2022-01-18T04:52:17Z | |
dc.date.available | 2022-01-18T04:52:17Z | |
dc.date.issued | 2022 | en_AU |
dc.identifier.uri | https://hdl.handle.net/2123/27333 | |
dc.description.abstract | Na+, Cl− and K+ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both Na+ and Cl− across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of K+ ions were present outside the vesicles. This unusual behaviour resulted from the strong affinity of the transporters for K+ ions, which led to predominant partitioning of the transporters as the K+ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with Na+, Cl− and K+ transport capabilities may have potential biological and medicinal applications. | en_AU |
dc.language.iso | en | en_AU |
dc.publisher | Springer Nature | en_AU |
dc.relation.ispartof | Frontiers of Chemical Science and Engineering | en_AU |
dc.subject | ion transport | en_AU |
dc.subject | thiourea | en_AU |
dc.subject | crown ether | en_AU |
dc.subject | symport | en_AU |
dc.title | Crown ether-thiourea conjugates as ion transporters | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | 0399 Other Chemical Sciences | en_AU |
dc.identifier.doi | 10.1007/s11705-021-2049-7 | |
dc.type.pubtype | Author accepted manuscript | en_AU |
dc.rights.other | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11705-021-2049-7 | en_AU |
dc.relation.other | National Natural Science Foundation of China 21820102006 | |
usyd.faculty | SeS faculties schools::Faculty of Science::School of Chemistry | en_AU |
usyd.department | SydneyNano | en_AU |
usyd.citation.volume | 16 | en_AU |
usyd.citation.issue | 1 | en_AU |
usyd.citation.spage | 81 | en_AU |
usyd.citation.epage | 91 | en_AU |
workflow.metadata.only | No | en_AU |
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