Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes

Hall, Andrew J.; Robertson, Amy G.; Hill, Leila R.; Rendina, Louis M.

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Open Access

Field	Value	Language
dc.contributor.author	Hall, Andrew J.
dc.contributor.author	Robertson, Amy G.
dc.contributor.author	Hill, Leila R.
dc.contributor.author	Rendina, Louis M.
dc.date.accessioned	2021-03-30T05:03:35Z
dc.date.available	2021-03-30T05:03:35Z
dc.date.issued	2021	en_AU
dc.identifier.uri	https://hdl.handle.net/2123/24767
dc.description.abstract	The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.	en_AU
dc.language.iso	en	en_AU
dc.publisher	Nature	en_AU
dc.relation.ispartof	Scientifc Reports	en_AU
dc.rights	Copyright All Rights Reserved	en_AU
dc.subject	gadolinium	en_AU
dc.subject	cell uptake	en_AU
dc.subject	delocalised lipophilic cation	en_AU
dc.subject	mitochondria	en_AU
dc.subject	neutron capture therapy	en_AU
dc.subject	photon activation therapy	en_AU
dc.subject	DOTA	en_AU
dc.title	Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes	en_AU
dc.type	Article	en_AU
dc.subject.asrc	03 Chemical Sciences	en_AU
dc.subject.asrc	0302 Inorganic Chemistry	en_AU
dc.subject.asrc	0304 Medicinal and Biomolecular Chemistry	en_AU
dc.identifier.doi	10.1038/s41598-020-79893-9
dc.relation.arc	DP190103461
usyd.faculty	SeS faculties schools::Faculty of Science::School of Chemistry	en_AU
usyd.faculty	Sydney Nano	en_AU
usyd.citation.volume	11	en_AU
usyd.citation.issue	1	en_AU
usyd.citation.spage	598	en_AU
workflow.metadata.only	No	en_AU