Tumor cell uptake and selectivity of gadolinium(III)-phosphonium complexes: The role of delocalisation at the phosphonium centre
Field | Value | Language |
dc.contributor.author | Busse, Madleen | |
dc.contributor.author | Windsor, Madeline S. A. | |
dc.contributor.author | Tefay, Alexander J. | |
dc.contributor.author | Kardashinsky, Mingyue | |
dc.contributor.author | Fenton, Jacob M. | |
dc.contributor.author | Morrison, Daniel E. | |
dc.contributor.author | Harris, Hugh H. | |
dc.contributor.author | Rendina, Louis M. | |
dc.date.accessioned | 2019-12-20 | |
dc.date.available | 2019-12-20 | |
dc.date.issued | 2017-12-01 | |
dc.identifier.citation | Journal of Inorganic Biochemistry 177 (2017) 313–321314 | en_AU |
dc.identifier.uri | https://hdl.handle.net/2123/21605 | |
dc.description.abstract | The synthesis of a series of bifunctional Gd(III) complexes 1–3 covalently bound to arylphosphonium cations possessing a varying degree of delocalisation at the phosphonium centre is presented. The influence of the degree of delocalisation was investigated with regards to in vitro cytotoxicity, cellular uptake of Gd, tumor-cell selectivity and intracellular localisation of Gd within human glioblastoma (T98G) and human glial (SVG p12) cells. Cellular uptake and selectivity studies for the Gd(III) complexes indicate that a reduced delocalisation at the phosphonium centre can lead to an enhanced Gd uptake into SVG p12 cells which results in a decrease in the overall tumor cell selectivity. Synchrotron X-ray fluorescence (microbeam XRF) imaging has demonstrated for the first time that uniform uptake of Gd(III) complex 2 within a population of T98G cells increased as a function of increasing Gd incubation times. The Gd maps show dispersed spots of high intensity which are consistent with mitochondrial uptake. | en_AU |
dc.description.sponsorship | Australian Research Council (ARC DP120100958 and ARC DP140100176) | en_AU |
dc.language.iso | en | en_AU |
dc.publisher | Elsevier | en_AU |
dc.relation | ARC DP120100958 | en_AU |
dc.subject | mitochondria | en_AU |
dc.subject | gadolinium | en_AU |
dc.subject | phosphonium | en_AU |
dc.subject | glioblastoma | en_AU |
dc.subject | XRF imaging | en_AU |
dc.title | Tumor cell uptake and selectivity of gadolinium(III)-phosphonium complexes: The role of delocalisation at the phosphonium centre | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | FoR::030201 - Bioinorganic Chemistry | en_AU |
dc.subject.asrc | FoR::030299 - Inorganic Chemistry not elsewhere classified | en_AU |
dc.subject.asrc | FoR::111204 - Cancer Therapy (excl. Chemotherapy and Radiation Therapy) | en_AU |
dc.subject.asrc | FoR::110302 - Clinical Chemistry (diagnostics) | en_AU |
dc.identifier.doi | 10.1016/j.jinorgbio.2017.07.004 | |
dc.type.pubtype | Post-print | en_AU |
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