The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane
| Field | Value | Language |
| dc.contributor.author | Austin, Christopher J. D. | |
| dc.contributor.author | Kahlert, Jan | |
| dc.contributor.author | Issa, Fatiah | |
| dc.contributor.author | Reed, John H. | |
| dc.contributor.author | Smith, Jason R. | |
| dc.contributor.author | Ioppolo, Joseph A. | |
| dc.contributor.author | Ong, Jennifer A. | |
| dc.contributor.author | Jamie, Joanne F. | |
| dc.contributor.author | Hibbs, David | |
| dc.contributor.author | Rendina, Louis M. | |
| dc.date.accessioned | 2019-12-20 | |
| dc.date.available | 2019-12-20 | |
| dc.date.issued | 2014-04-22 | |
| dc.identifier.citation | Dalton Trans., 2014,43, 10719-10724 | en |
| dc.identifier.uri | https://hdl.handle.net/2123/21598 | |
| dc.description.abstract | Indoleamine-2,3-dioxygenase-1 (IDO1) is a critical immunoregulatory enzyme responsible for the metabolism of tryptophan during inflammation and disease. Based upon a pyranonaphthoquinone framework, the first examples of indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing a carborane cage are reported. The novel closo-1,2-carboranyl-N-pyranonaphthoquinone derivatives display low μM binding affinity for the human recombinant enzyme, with IC50 values ranging from 0.78 to 1.77 μM. | en |
| dc.description.sponsorship | Australian Research Council (ARC), NBCF | en |
| dc.language.iso | en | en |
| dc.publisher | Royal Society of Chemistry | en |
| dc.relation | ARC | en |
| dc.rights | Other | en |
| dc.subject | IDO1 inhibitors | en |
| dc.subject | indoleamine-2,3-dioxygenase-1 inhibitors | en |
| dc.subject | indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors | en |
| dc.subject | carborane | en |
| dc.subject | boron | en |
| dc.subject | clusters | en |
| dc.subject | boron clusters | en |
| dc.title | The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane | en |
| dc.type | Article | en |
| dc.subject.asrc | FoR::030299 - Inorganic Chemistry not elsewhere classified | en |
| dc.subject.asrc | FoR::030205 - Non-metal Chemistry | en |
| dc.subject.asrc | FoR::110103 - Medical Biochemistry: Inorganic Elements and Compounds | en |
| dc.type.pubtype | Author accepted manuscript | en |
| usyd.faculty | Faculty of Science, School of Chemistry |
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