Sulfate selective recognition using neutral dipeptide anion receptors in aqueous solution
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Open Access
Type
ArticleAbstract
The synthesis of six small peptide anion receptors based on thiourea and squaramide recognition moieties is described. These new receptors bind to tetrahedral sulfate anions with remarkable affinity and selectivity in aqueous solution as shown by NMR spectroscopy. Molecular modelling suggests that selectivity is mediated by a hydrogen bond network incorporating the amide backbone protons in a manner similar to that found in the sulfate-binding protein.The synthesis of six small peptide anion receptors based on thiourea and squaramide recognition moieties is described. These new receptors bind to tetrahedral sulfate anions with remarkable affinity and selectivity in aqueous solution as shown by NMR spectroscopy. Molecular modelling suggests that selectivity is mediated by a hydrogen bond network incorporating the amide backbone protons in a manner similar to that found in the sulfate-binding protein.
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Date
2014-01-01Publisher
WileyLicence
OtherRights statement
This is the peer reviewed version of the following article: Elmes, R. B. P., K. Y. Yuen, K., & Jolliffe, K. A. (2014). Sulfate-Selective Recognition by Using Neutral Dipeptide Anion Receptors in Aqueous Solution. Chemistry - A European Journal, 20(24), 7373–7380. https://doi.org/10.1002/chem.201400292which has been published in final form at 10.1002/chem.201400292. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Faculty/School
Faculty of Science, School of ChemistryCitation
Elmes, R. B. P., K. Y. Yuen, K., & Jolliffe, K. A. (2014). Sulfate-Selective Recognition by Using Neutral Dipeptide Anion Receptors in Aqueous Solution. Chemistry - A European Journal, 20(24), 7373–7380. https://doi.org/10.1002/chem.201400292Share