Passive Tumour Targeting and Extravasation of Cylindrical Polymer Brushes in Mouse Xenografts
| Field | Value | Language |
| dc.contributor.author | Muellner, Markus | |
| dc.contributor.author | Mehta, Dharmini | |
| dc.contributor.author | Nowell, Cameron J. | |
| dc.contributor.author | Porter, Christopher J.H. | |
| dc.date.accessioned | 2019-11-21 | |
| dc.date.available | 2019-11-21 | |
| dc.date.issued | 2016-03-17 | |
| dc.identifier.citation | Chem. Commun., 2016, 52, 9121-9124 DOI: 10.1039/C6CC00447D | en |
| dc.identifier.uri | https://hdl.handle.net/2123/21392 | |
| dc.description.abstract | The shape-persistent nature and cylindrical conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic (ie non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 µm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs. | en |
| dc.description.sponsorship | This research was financially supported by The University of Sydney (M.M.) and the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (C.J.H.P., CE140100036). | en |
| dc.language.iso | en | en |
| dc.publisher | Royal Society of Chemistry (RSC) | en |
| dc.relation | ARC CE140100036 | en |
| dc.rights | Other | en |
| dc.subject | Polymer Brushes | en |
| dc.subject | nanomedicine | en |
| dc.subject | in vivo | en |
| dc.title | Passive Tumour Targeting and Extravasation of Cylindrical Polymer Brushes in Mouse Xenografts | en |
| dc.type | Article | en |
| dc.subject.asrc | 030304 | en |
| dc.type.pubtype | Post-print | en |
| usyd.faculty | Faculty of Science, School of Chemistry |
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