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dc.contributor.authorClarke, Ronald J.
dc.date.accessioned2019-09-04
dc.date.available2019-09-04
dc.date.issued2019-01-01
dc.identifier.citationClarke, R. J. (2019). Effect of Cholesterol on the Dipole Potential of Lipid Membranes. In Advances in Experimental Medicine and Biology (pp. 135–154). Springer International Publishing. https://doi.org/10.1007/978-3-030-04278-3_6en_AU
dc.identifier.isbn978-3-030-04278-3
dc.identifier.urihttp://hdl.handle.net/2123/21020
dc.description.abstractThe membrane dipole potential, ψd, is an electrical potential difference with a value typically in the range 150 – 350 mV (positive in the membrane interior) which is located in the lipid headgroup region of the membrane, between the linkage of the hydrocarbon chains to the phospholipid glycerol backbone and the adjacent aqueous solution. At its physiological level in animal plasma membranes (up to 50 mol%), cholesterol makes a significant contribution to ψd of approximately 65 mV; the rest arising from other lipid components of the membrane, in particular phospholipids. Via its effect on ψd, cholesterol may modulate the activity of membrane proteins. This could occur through preferential stabilization of protein conformational states. Based on its effect on ψd, cholesterol would be expected to favour protein conformations associated with a small local hydrophobic membrane thickness. Via its membrane condensing effect, which also produces an increase in ψd, cholesterol could further modulate interactions of polybasic cytoplasmic extensions of membrane proteins, in particular P-type ATPases, with anionic lipid headgroups on the membrane surface, thus leading to enhanced conformational stabilization effects and changes to ion pumping activity.en_AU
dc.description.sponsorshipAustralian Research Councilen_AU
dc.language.isoen_AUen_AU
dc.publisherSpringeren_AU
dc.relationARC DP121003548, ARC DP150101112, ARC DP170101732en_AU
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in In Advances in Experimental Medicine and Biology. The final authenticated version is available online at: https://doi.org/10.1007/978-3-030-04278-3_6
dc.subjectlipid headgroupen_AU
dc.subjectoxysterolsen_AU
dc.subjectlipid packingen_AU
dc.subjecthydrophobic thicknessen_AU
dc.subjection channelsen_AU
dc.subjection pumpsen_AU
dc.titleEffect of cholesterol on the dipole potential of lipid membranesen_AU
dc.typeArticleen_AU
dc.subject.asrcFoR::030403 - Characterisation of Biological Macromoleculesen_AU
dc.identifier.doidoi.org/10.1007/978-3-030-04278-3_6
dc.type.pubtypePost-printen_AU


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