Browsing School of Chemistry by subject "0399 Other Chemical Sciences"
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Acridinone-based anion transporters
Published 2021The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea ...Open AccessArticle -
Binding and transport properties of a benzo[b]thiophene-based mono-(thio)urea library
Published 2021Using the chemical versatility of the benzo[ b ]thiophene motif, an extensive library of 24 (thio)urea receptors, with different binding properties and lipophilicities was prepared and included α,α-, α,β-, β,β-, β,γ-, α,γ-, ...Open AccessArticle -
Carbazole-based bis-ureas and thioureas as electroneutral anion transporters
Published 2021We report a series of easily accessible carbazole-based bis-ureas and thioureas as effective anion receptors and transporters. The compounds exhibit moderate Cl− binding affinity in wet DMSO and Cl− transport capabilities ...Open AccessArticle -
Crown ether-thiourea conjugates as ion transporters
Published 2022Na+, Cl− and K+ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic ...Open AccessArticle -
Delivering anion transporters to lipid bilayers in water
Published 2021Cyclodextrins have been employed as delivery agents for lipophilic anion transporters, which allow their incorporation into lipid bilayers without using an organic solvent or pre-incorporation.Open AccessArticle -
E_File_8 - Chapter 4 DFT optimised coordinates.zip
Published 2018Zip archive folder of all Density-Functional Theory optimised molecular structures (Cartesian coordinates) reported in Thesis Chapter 4.Open AccessDataset -
Halide-selective, proton-coupled anion transport by phenylthiosemicarbazones
Published 2022Phenylthiosemicarbazones (PTSCs) are proton-coupled anion transporters with pH-switchable behaviour known to be regulated by an imine protonation equilibrium. Previously, chloride/nitrate exchange by PTSCs was found to be ...Open AccessArticle -
Measuring anion transport selectivity: a cautionary tale
Published 2021pH-dependent liposomal assays are often used to determine anion selectivity in transmembrane anion transport experiments. We discuss the validity and limitations of these assays, and provide guidelines for their use to ...Open AccessArticle -
Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas
Published 2021Membrane transport proteins fulfil important regulatory functions in biology with a common trait being their ability to respond to stimuli in the environment. Various small-molecule receptors, capable of mediating transmembrane ...Open AccessArticle -
Progress in Anion Receptor Chemistry
Published 2022This review covers advances made in anion complexation in the years 2019 and 2020. Included here are developments in self-assembly, sensing, anion separation, transport, catalysis, and fundamental advances in anion recognition ...Open AccessArticle -
Synthetic Na+/K+ exchangers promote apoptosis by disturbing cellular cation homeostasis
Published 2021A number of artificial cation ionophores (or transporters) have been developed for basic research and biomedical applications. However, their mechanisms of action and the putative correlations between changes in intracellular ...Open AccessArticle -
A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment
Published 2021The selective and efficient capture of phosphopeptides is critical for comprehensive and in-depth phosphoproteome analysis. Reported here is a new switchable two-dimensional (2D) supramolecular polymer that can serve as ...Open AccessArticle