Faculty of Science: Recent submissions
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Stereoselective Synthesis of Sialylated Tumor-Associated Glycosylamino Acids
Published 2013-10-25Suitably protected sialyl TN and 2,6-sialyl T tumor-associated carbohydrate antigen-derived amino acids have been prepared stereoselectively using an oxazolidinone-derived sialoside donor. These glycosylamino acids can be ...Open AccessArticle -
Total Synthesis of Skyllamycins
Published 2017-09-14The skyllamycins are a family of highly functionalized non‐ribosomal cyclic depsipeptide natural products which contain the extremely rare α‐OH‐glycine functionality. Herein the first total synthesis of skyllamycins A–C ...Open AccessArticle -
Total Synthesis of Homogeneous Variants of Hirudin P6: A Post‐Translationally Modified Anti‐Thrombotic Leech‐Derived Protein
Published 2014-03-11Hirudin P6 is a leech‐derived anti‐thrombotic protein which possesses two post‐translational modifications, O ‐glycosylation and tyrosine sulfation. In this study we report the ligation‐based synthesis of a library of ...Open AccessArticle -
Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation- Desulfurization Chemistry
Published 2015-04-10The efficient synthesis of a β-thiol phenylalanine derivative is described starting from Garner’s aldehyde. The utility of this amino acid in peptide ligation–desulfurization chemistry is described, including the ...Open AccessArticle -
Chemoselective Peptide Ligation–Desulfurization Chemistry at Aspartate
Published 2013-07-24Asp‐ecially useful : A synthetic β‐mercapto aspartate residue facilitates the rapid ligation to a range of peptide thioesters. Following the ligation reaction (and without purification), chemoselective desulfurization of ...Open AccessArticle