Faculty of Science: Recent submissions
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Total Synthesis of Teixobactin
Published 2016-05-18The first total synthesis of the cyclic depsipeptide natural product teixobactin is described. Synthesis was achieved by solid-phase peptide synthesis, incorporating the unusual l-allo-enduracididine as a suitably protected ...Open AccessArticle -
Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−Desulfurization Chemistry
Published 2014-05-15Native chemical ligation followed by desulfurization is a powerful strategy for the assembly of proteins. Here we describe the development of a high-yielding, one-pot ligation−desulfurization protocol that uses ...Open AccessArticle -
Total Synthesis of Native 5,7-Diacetylpseudaminic Acid from N-Acetylneuraminic Acid
Published 2016-02-23The pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are functional components of flagellin and pili proteins within clinically relevant Gram-negative bacteria. Herein, we describe the ...Open AccessArticle -
One-Pot Peptide Ligation–Desulfurization at Glutamate
Published 2013-12-02An efficient methodology for ligation at glutamate (Glu) is described. A γ-thiol-Glu building block was accessed in only three steps from protected glutamic acid and could be incorporated at the N-terminus of peptides. The ...Open AccessArticle -
Total Synthesis of Polydiscamides B, C, and D via a Convergent Native Chemical Ligation–Oxidation Strategy
Published 2014-08-08The first total syntheses of the marine sponge-derived cyclic depsipeptide natural products Polydiscamides B, C, and D are described. The molecules were constructed through the convergent fusion of cyclic and linear fragments ...Open AccessArticle