Chemoselective Peptide Ligation–Desulfurization Chemistry at Aspartate

Abstract

Asp‐ecially useful : A synthetic β‐mercapto aspartate residue facilitates the rapid ligation to a range of peptide thioesters. Following the ligation reaction (and without purification), chemoselective desulfurization of the β‐mercapto moiety in the presence of unprotected cysteine residues afforded native peptide products.