Faculty of Science: Recent submissions
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Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate
Published 2017-02-01Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide. The biological function of this flexible macrocycle is obscure. Here we show that compound 1 lacks any detectable activity in antimicrobial growth ...Open AccessArticle -
Anion transport and supramolecular medicinal chemistry
Published 2017-01-01New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. ...Open AccessArticle -
Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents
Published 2017-01-01Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H+/Cl− ...Open AccessArticle -
A tripodal tris-selenourea anion transporter matches the activity of its thio- analogue but shows distinct selectivity
Published 2018-01-01We report the synthesis of a tripodal tris-selenourea transporter scaffold. The Cl− and NO− 3 transport activity of the compound has been compared extensively with the analogous oxo- and thiourea compounds. We found that ...Open AccessArticle -
Fluorinated tripodal receptors for potentiometric chloride detection in biological fluids
Published 2017-07-01Fluorinated tripodal compounds were recently reported to be efficient transmembrane transporters for a series of inorganic anions. In particular, this class of receptors has been shown to be suitable for the effective ...Open AccessArticle