Browsing by author "Wu, Xin"
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Advances in Anion Receptor Chemistry
Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.Published 2020-01-01This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...Open AccessArticle -
Anion binding in metal-organic frameworks
Wu, Xin; Gale, Philip A.Published 2021Despite commonly being used as the host for gases, solvents and other neutral molecules, metal-organic frameworks (MOFs) have received recent attention as supramolecular anion binding hosts with a broad range of environmental ...Open AccessPreprint -
Anion receptor chemistry: Highlights from 2016
Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin; Spooner, Michael J.Published 2018-02-01This review covers recent advances in anion receptor chemistry from 2016, including developments in self-assembly, sensing, anion separation, transport, catalysis and fundamental advances in anion recognition systems.Open AccessArticle -
Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter
Rawling, Tristan; MacDermott-Opeskin, Hugh; Roseblade, Ariane; Pazderka, Curtis; Clarke, Callum; Bourget, Kirsi; Wu, Xin; Lewis, William; Noble, Benjamin; Gale, Philip A.; O'Mara, Megan L.; Cranfield, Charles; Murray, MichaelPublished 2020Respiring mitochondria establish a proton gradient across the mitochondrial inner membrane (MIM) that is used to generate ATP. Protein-independent mitochondrial uncouplers collapse the proton gradient and disrupt ATP ...Open AccessArticle -
Carbazole-based bis-ureas and thioureas as electroneutral anion transporters
Wang, Patrick; Wu, Xin; Gale, Philip A.Published 2021We report a series of easily accessible carbazole-based bis-ureas and thioureas as effective anion receptors and transporters. The compounds exhibit moderate Cl− binding affinity in wet DMSO and Cl− transport capabilities ...Open AccessArticle -
Crown ether-thiourea conjugates as ion transporters
Zhao, Zhixing; Tang, Bailing; Yan, Xiaosheng; Wu, Xin; Li, Zhao; Gale, Philip A.; Jiang, Yun-BaoPublished 2022Na+, Cl− and K+ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic ...Open AccessArticle -
Design of Chiral Supramolecular Polymers Exhibiting a Negative Nonlinear Response
Chen, Xuan-Xuan; Lin, Xiao-Yan; Wu, Xin; Gale, Philip A.; Anslyn, Eric V.; Jiang, Yun-BaoPublished 2019-01-01Many synthetic and supramolecular chiral polymeric systems are known to exhibit the “majority rules effect” (MRE), a positive nonlinear response in which a small enantiomeric excess (ee) of the chiral building blocks leads ...Open AccessArticle -
Dissecting the chloride–nitrate anion transport assay
Yang, Yufeng; Wu, Xin; Busschaert, Nathalie; Furuta, Hiroyuki; Gale, Philip A.Published 2017-07-01A systematic study of chloride vs. nitrate selectivity across six anion transporters has revealed a good correlation between the selectivities of their anion binding and membrane transport properties. This work reveals the ...Open AccessArticle -
Fluorescent squaramides as anion receptors and transmembrane anion transporters
Bao, Xiaoping; Wu, Xin; Berry, Stuart N.; Howe, Ethan N.W.; Chang, Young-Tae; Gale, Philip A.Published 2018-01-01A series of squaramide-based anion transporters functionalised with the 1,8-naphthalimide fluorophore has been developed for improved ionophoric activity and fluorescent imaging in cells.Open AccessArticle -
Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport
Spooner, Michael J.; Li, Hongyu; Marques, Igor; Costa, Pedro M.R.; Wu, Xin; Howe, Ethan N.W.; Busschaert, Nathalie; Moore, Stephen J.; Light, Mark E.; Sheppard, David N.; Gale, Philip A.Published 2018-01-01A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate their mechanism of action using anion transport assays in cells ...Open AccessArticle -
Halide-selective, proton-coupled anion transport by phenylthiosemicarbazones
Howe, Ethan N.W.; Chang, Vai-Vai Tiffany; Wu, Xin; Fares, Mohamed; Lewis, William; Macreadie, Lauren K.; Gale, Philip A.Published 2022Phenylthiosemicarbazones (PTSCs) are proton-coupled anion transporters with pH-switchable behaviour known to be regulated by an imine protonation equilibrium. Previously, chloride/nitrate exchange by PTSCs was found to be ...Open AccessArticle -
Investigating the Influence of Steric Hindrance on Selective Anion Transport
Jowett, Laura A.; Ricci, Angela; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.Published 2019-04-02A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied. Overall, increasing the steric bulk of the substituents ...Open AccessArticle -
Measuring anion transport selectivity: a cautionary tale
Wu, Xin; Gale, Philip A.Published 2021pH-dependent liposomal assays are often used to determine anion selectivity in transmembrane anion transport experiments. We discuss the validity and limitations of these assays, and provide guidelines for their use to ...Open AccessArticle -
New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas
Jowett, Laura A.; Howe, Ethan N.W.; Wu, Xin; Busschaert, Nathalie; Gale, Philip A.Published 2018-06-19The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism ...Open AccessArticle -
Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas
Wezenberg, Sander J.; Chen, Li-Jun; Howe, Ethan N.W.; Wu, Xin; Siegler, Maxime A.; Gale, Philip A.; Bos, Jasper E.; Feringa, Ben L.Published 2021Membrane transport proteins fulfil important regulatory functions in biology with a common trait being their ability to respond to stimuli in the environment. Various small-molecule receptors, capable of mediating transmembrane ...Open AccessArticle -
Prospects and Challenges in Anion Recognition and Transport
Wu, Xin; Gilchrist, Alexander M.; Gale, Philip A.Published 2020-01-01The genesis of anion receptor chemistry can be traced back to the late 1960s with the work of Shriver and Biallas on chelating Lewis acids and Park and Simmons on ammonium-containing cryptandlike halide receptors. Despite ...Open AccessArticle -
Selective anion transport mediated by strap-extended calixpyrroles
Clarke, Harriet J.; Wu, Xin; Light, Mark E.; Gale, Philip A.Published 2020-01-01Synthetic anion receptors that facilitate transmembrane chloride transport are of interest as potential therapeutic agents for cancer and cystic fibrosis. Transporters selective for chloride over protons are desired for ...Open AccessArticle -
Stimuli-responsive cycloaurated ‘OFF-ON’ switchable anion transporters
Fares, Mohamed; Wu, Xin; Ramesh, Deepthi; Lewis, William; Keller, Paul A.; Howe, Ethan N.W.; Pérez-Tomás, Ricardo; Gale, Philip A.Published 2020-01-01Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes ...Open AccessArticle -
Supramolecular transmembrane anion transport: new assays and insights
Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.Published 2018Transmembrane anion transport has been the focus of a number of supramolecular chemistry research groups for a number of years. Much of this research is driven by the biological relevance of anion transport and the search ...Open AccessArticle -
Tetrapodal Anion Transporters
Gilchrist, Alexander M.; Chen, Lijun; Wu, Xin; Lewis, William; Howe, Ethan N.W.; Macreadie, Lauren K.; Gale, Philip A.Published 2020-01-01Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via ...Open AccessArticle
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