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    • A latent green fluorescent styrylcoumarin probe for the selective growth and detection of Gram negative bacteria 

      Váradi, Linda; Wang, Miaoyi; Mamidi, Ramesh R; Perry, John D.; Hibbs, David E.; Groundwater, Paul W.
      Published 2018-07-11
      A novel, green fluorescent β-alanylstyrylcoumarin derivative was synthesized and evaluated for its performance as a fluorogenic enzyme substrate on a range of clinically relevant microorganisms. The substrate was selectively ...
      Open Access
      Preprint
      View
    • Loading of a Phenanthroline-Based Platinum(II) Complex onto the Surface of a Carbon Nanotube via pi–pi Stacking 

      Houston, Stephanie; Venkataramanan, Natarajan; Suvitha, Ambigapathy; Wheate, Nial
      Published 2016-11-01
      Stacking of the metal complex [(5,6-dimethyl-1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2þ (56MESS) onto the surface of two different fullerenes, a carbon nanotube (CNT), and a C60-buckyball was examined. ...
      Open Access
      Article
      View
    • Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. 

      Arabi, Yaseen M; Gordon, Anthony C; Derde, Lennie P G; Nichol, Alistair D; Murthy, Srinivas; Beidh, Farah Al; Annane, Djillali; Swaidan, Lolowa Al; Beane, Abi; Beasley, Richard; Berry, Lindsay R; Bhimani, Zahra|Bonten, Marc J M; Bradbury, Charlotte A; Brunkhorst, Frank M; Buxton, Meredith; Buzgau, Adrian; Cheng, Allen; De Jong, Menno; Detry, Michelle A; Duffy, Eamon J; Estcourt, Lise J; Fitzgerald, Mark; Fowler, Rob; Girard, Timothy D; Goligher, Ewan C; Goossens, Herman; Haniffa, Rashan; Higgins, Alisa M; Hills, Thomas E; Horvat, Christopher M; Huang, David T; King, Andrew J; Lamontagne, Francois; Lawler, Patrick R; Lewis, Roger; Linstrum, Kelsey; Litton, Edward; Lorenzi, Elizabeth; Malakouti, Salim; McAuley, Daniel F; McGlothlin, Anna; Mcguinness, Shay; McVerry, Bryan; Montgomery, Stephanie K; Morpeth, Susan C; Mouncey, Paul R; Orr, Katrina; Parke, Rachael; Parker, Jane C; Patanwala, Asad E; Rowan, Kathryn M; Santos, Marlene S; Saunders, Christina T; Seymour, Christopher W; Shankar-Hari, Manu; Tong, Steven Y C; Turgeon, Alexis F; Turner, Anne M; Van de Veerdonk, Frank Leo; Zarychanski, Ryan; Green, Cameron; Berry, Scott; Marshall, John C; McArthur, Colin; Angus, Derek C; Webb, Steven A; REMAP-CAP Investigators
      Published 2021
      PURPOSE: To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). METHODS: Critically ill adults with COVID-19 were randomized to receive ...
      Article
      View
    • Medications in Post-Acute and Long-Term Care: Challenges and Controversies 

      Sloane, P.D.; Brandt, N.J.; Cherubini, A.; Dharmarajan, T.S.; Dosa, D.; Hanlon, J.T.; Katz, P.; Koopmans, R.T.C.M.; Laird,R.D.; Petrovic, M.; Semla, T.P.; Tan, E.C.K.; Zimmerman, S.
      Published 2021
      Article
      View
    • Microfluidic-assisted bacteriophage encapsulation into liposomes 

      Leung, Sharon SY; Morales, Sandra; Britton, Warwick; Kutter, Elizabeth; Chan, Hak-Kim
      Published 2018-07-10
      Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows reproducible mixing in miliseconds on the nanoliter scale. Here we investigated the feasibility of a microfluidic flow focusing ...
      Open Access
      Article
      View
    • Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design 

      Khatib, Isra; Chow, Michael YT; Ruan, Juanfang; Cipolla, David; Chan, Hak-Kim
      Published 2021
      Spray drying was previously used to modify the physical form of the encapsulated ciprofloxacin drug to produce ciprofloxacin nanocrystals inside the liposomes (CNL). The purpose of the present study was to optimize CNL ...
      Open Access
      Article
      View
    • Nanoparticles: the future for platinum drugs or a research red herring? 

      Wheate, Nial
      Published 2012-01-01
      Open Access
      Article
      View
    • Nanoscale probing of liposome encapsulating drug nanocrystal using Atomic Force Microscopy-Infrared Spectroscopy 

      Khanal, Dipesh; Khatib, Isra; Ruan, Juanfang; Cipolla, David; Dayton, Francis; Blanchard, James; Chan, Hak-Kim; Chrzanowski, Wojciech
      Published 2020
      Use of liposomes encapsulating drug nanocrystals for the treatment of diseases like cancer and pulmonary infections is gaining attention. The potential therapeutic benefit of these engineered formulations relies on maintaining ...
      Open Access
      Article
      View
    • A Narrative Review of COVID-19 Vaccines 

      Eroglu, B.; Nuwarda, R.F.; Ramzan, I.; Kayser, V.
      Published 2022
      The COVID-19 pandemic has shaken the world since early 2020 and its health, social, economic, and societal negative impacts at the global scale have been catastrophic. Since the early days of the pandemic, development of ...
      Other
      View
    • Nebulisation effects on structural stability of bacteriophage PEV44 

      Astudillo, Ariel; Leung, Sharon Shui Yee; Kutter, Elizabeth; Morales, Sandra; Britton, Warwick J; Chan, Hak-Kim
      Published 2017-08-11
      Nebulization being used for inhaled phage therapy can cause phage titer losses which may be the result of mechanical damage to the phages. This study aimed to determine effects of nebulization on the structural stability ...
      Open Access
      Conference paper
      View
    • Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19 

      Tai, Waiting; Chow, Michael Yee Tak; Chang, Rachel Yoon Kyung; Tang, Patricia; Gonda, Igor; MacArthur, Robert B; Chan, Hak-Kim; Kwok, Philip Chi Lip
      Published 2021
      The coronavirus disease 2019 (COVID-19) is an unprecedented pandemic that has severely impacted global public health and the economy. Hydroxychloroquine administered orally to COVID-19 patients was ineffective, but its ...
      Article
      View
    • Nebulization effects on structural stability of bacteriophage PEV 44 

      Astudillo, Ariel; Leung, Sharon Shui Yee; Kutter, Elizabeth; Morales, Sandra; Chan, Hak-Kim
      Published 2018-01-17
      Reduced infectivity of phage due to the nebulization process has been reported previously, but no visual evidence on structural change upon nebulization has been established, or whether these structural changes can be ...
      Open Access
      Article
      View
    • "Never waste a good crisis": Opportunities and constraints from the COVID-19 pandemic on pharmacists' scope of practice 

      Chiu, Kellia; Thow, Anne Marie; Bero, Lisa
      Published 2022
      BACKGROUND: In response to the COVID-19 pandemic, many pharmacy-based or pharmacist-delivered services were introduced or amended to mitigate the pandemic's health and social impact. This happened within the context of ...
      Article
      View
    • New chemical and biological entities approved by the Therapeutic Goods Administration, January 1, 2005 to May 7, 2024 

      Lexchin, Joel; Hooimeyer, Ashleigh
      Published 2024-12-02
      This dataset includes information on drug approvals by the Australian Therapeutic Goods Administration (TGA) from 2005 to May 2024. Generic, brand name, indication, approval pathway (when applicable), and date of approval ...
      Open Access
      Dataset
      View
    • NON-ADHERENCE TO PATIENT SAFETY GUIDELINES: AN EVOLUTIONARY, ECOLOGICAL HYPOTHESIS 

      de Almeida Neto, Abílio César
      Published 2012-04-16
      Often well meaning health care workers do not adhere to patient safety guidelines or recommendations, with serious consequences; patient injuries and mortality. Non-adherence has been attributed to external limitations, ...
      Open Access
      Article
      View
    • Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles 

      Wheate, Nial J.; Taleb, Robin I.; Krause-Heuer, Anwen M.; Cook, Rebekah L.; Wang, Shaoyu; Higgins, Vincent J.; Aldrich-Wright, Janice R.
      Published 2007-01-01
      Open Access
      Article
      View
    • A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2 

      Xi, C.R.; Di Fazio, A.; Nadvi, N.A.; Patel, K.; Xiang, M.S.W.; Zhang, H.E.; Deshpande, C.; Low, J.K.K.; Wang, X.T.; Chen, Y.; McMillan, C.L.D.; Isaacs, A.; Osborne, B.; Vieira de Ribeiro, A.J.; McCaughan, G.W.; Mackay, J.P.; Church, W.B.; Gorrell, M.D.
      Published 2020
      Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is a pharmacological target in type 2 diabetes therapy ...
      Article
      View
    • Participants’ experiences of and perceived value regarding different support types for long-term condition self-management programmes 

      Lewis, Sophie; Willis, Karen; Wyke, Sally; Rogers, Anne; Smith, Lorraine; Hughes, Stephen John
      Published 2019-08-19
      Objectives Health professional-led group programmes are a common form of long-term condition self-management support. Much research has focused on clinical outcomes of group participation, yet there is limited research on ...
      Open Access
      Article
      View
    • Persistent postoperative opioid use after total hip or knee arthroplasty: A systematic review and meta-analysis 

      Tay, Hui Ping; Wang, Xinyi; Narayan, Sujita W; Penm, Jonathan; Patanwala, Asad E
      Published 2021
      DISCLAIMER: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed ...
      Article
      View
    • Pharmaceutical industry funding of events for Australian healthcare professionals (October 2015 to October 2018) 

      Karanges, Emily; Fabbri, Alice; Glendinning, Emma; Mintzes, Barbara; Bero, Lisa
      Published 2019-06-01
      The dataset contains reports of pharmaceutical company sponsorship of educational events for healthcare professionals organised by third parties (such as medical colleges and societies, hospitals, universities, and other ...
      Open Access
      Dataset
      View
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