• Healthcare Workers' Knowledge and Perception of the SARS-CoV-2 Omicron Variant: A Multinational Cross-Sectional Study 

      Bhagavathula, Akshaya Srikanth; Mahabadi, Mohammadjavad Ashrafi; Tesfaye, Wubshet; Nayar, Kesavan Rajasekharan; Chattu, Vijay Kumar
      Published 2022
      In late November 2021, a new SARS-CoV-2 Variant of Concern (VOC) named Omicron (initially named B.1.1.529) was first detected in South Africa. The rapid spread of the SARS-CoV-2 Omicron variant became globally dominant, ...
      Article
    • How do facilitators of group programmes for long-term conditions conceptualise self-management support? 

      Hughes, Stephen John; Lewis, Sophie; Willis, Karen; Wyke, Sally; Rogers, Anne; Smith, Lorraine
      Published 2018-08-01
      Objectives Increasing self-management skills in people with long-term conditions is widely advocated in policies and guidelines. Group programmes are a common format; yet, how self-management support objectives are enacted ...
      Open Access
      Article
    • Improving the Uptake of the Australian Home Medicines Review through Patient Segmentation 

      White, Lesley; Klinner, Christiane; Cobelli, Nicola
      Published 2011-01-01
      The Australian Home Medicines Review (HMR) Program, aimed at reducing the number of medication-related problems and hospital admissions, has not been used to the extent projected and is little known among eligible consumers. ...
      Open Access
      Article
    • INCREASING PATIENT DEMAND FOR HOME MEDICINES REVIEWS: A MARKETING PLAN 

      White, L; Clark, C; Klinner, Christiane
      Published 2010-02-01
      Campbell (2008)stated that “Consumer awareness of the program is of major concern” and concluded that “all stakeholders agreed that the Home Medicines Review (HMR) Program should be promoted more to consumers and carers.” ...
      Open Access
      Conference poster
    • INCREASING PATIENT DEMAND FOR HOME MEDICINES REVIEWS: A MARKETING PLAN RESEARCH STUDY 

      White, L; Carter, Stephen R; Klinner, Christiane; Clark, C
      Published 2010-02-01
      Objectives: 1. To deliver a marketing plan which proposes strategies to increase consumer uptake of HMRs. Sub -objectives were to assess the:  Awareness levels of eligible non-recipients prior to participation in this ...
      Open Access
      Conference poster
    • Inhalable Hydroxychloroquine Powders for Potential Treatment of COVID-19 

      Albariqi, Ahmed H.; Chang, Rachel Yoon Kyung; Tai, Waiting; Ke, Wei-Ren; Chow, Michael Y.T.; Tang, Patricia; Kwok, Philip Chi Lip; Chan, Hak-Kim
      Published 2021
      Background: Hydroxychloroquine (HCQ) is one of the repurposed drugs proposed for the treatment of coronavirus disease 2019 (COVID-19). However, all the published clinical trials involve oral administration of the drug, ...
      Article
    • Intestinal Dysbiosis, the Tryptophan Pathway and Nonalcoholic Steatohepatitis. 

      Chen, Jiezhong; Vitetta, Luis; Henson, Jeremy D; Hall, Sean
      Published 2022
      Non-alcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH), which may then progress to the development of cirrhosis and hepatocarcinoma. NASH is characterized by both steatosis and ...
      Open Access
      Article
    • The intestinal microbiota and improving the efficacy of COVID-19 vaccinations 

      Chen, Jiezhong; Vitetta, Luis; Henson, Jeremy D; Hall, Sean
      Published 2021
      Most COVID-19 cases are mild or asymptomatic and recover well, suggesting that effective immune responses ensue, which successfully eliminate SARS-CoV-2 viruses. However, a small proportion of patients develop severe ...
      Open Access
      Article
    • Jet nebulization of bacteriophages with different tail morphologies – structural effects 

      Leung, Sharon SY; Carrigy, Nicholas B; Vehring, Reinhard; Finlay, Warren H; Morales, Sandra; Carter, Elizabeth A; Britton, Warwick J; Kutter, Elizabeth; Chan, Hak-Kim
      Published 2019-01-10
      It was previously demonstrated that the loss of infectivity of a myovirus PEV44 after jet nebulization was closely related to a change in bacteriophage (phage) structure. In this follow-up study, we further examined the ...
      Open Access
      Article
    • A latent green fluorescent styrylcoumarin probe for the selective growth and detection of Gram negative bacteria 

      Váradi, Linda; Wang, Miaoyi; Mamidi, Ramesh R; Perry, John D.; Hibbs, David E.; Groundwater, Paul W.
      Published 2018-07-11
      A novel, green fluorescent β-alanylstyrylcoumarin derivative was synthesized and evaluated for its performance as a fluorogenic enzyme substrate on a range of clinically relevant microorganisms. The substrate was selectively ...
      Open Access
      Preprint
    • Loading of a Phenanthroline-Based Platinum(II) Complex onto the Surface of a Carbon Nanotube via pi–pi Stacking 

      Houston, Stephanie; Venkataramanan, Natarajan; Suvitha, Ambigapathy; Wheate, Nial
      Published 2016-11-01
      Stacking of the metal complex [(5,6-dimethyl-1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2þ (56MESS) onto the surface of two different fullerenes, a carbon nanotube (CNT), and a C60-buckyball was examined. ...
      Open Access
      Article
    • Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. 

      Arabi, Yaseen M; Gordon, Anthony C; Derde, Lennie P G; Nichol, Alistair D; Murthy, Srinivas; Beidh, Farah Al; Annane, Djillali; Swaidan, Lolowa Al; Beane, Abi; Beasley, Richard; Berry, Lindsay R; Bhimani, Zahra|Bonten, Marc J M; Bradbury, Charlotte A; Brunkhorst, Frank M; Buxton, Meredith; Buzgau, Adrian; Cheng, Allen; De Jong, Menno; Detry, Michelle A; Duffy, Eamon J; Estcourt, Lise J; Fitzgerald, Mark; Fowler, Rob; Girard, Timothy D; Goligher, Ewan C; Goossens, Herman; Haniffa, Rashan; Higgins, Alisa M; Hills, Thomas E; Horvat, Christopher M; Huang, David T; King, Andrew J; Lamontagne, Francois; Lawler, Patrick R; Lewis, Roger; Linstrum, Kelsey; Litton, Edward; Lorenzi, Elizabeth; Malakouti, Salim; McAuley, Daniel F; McGlothlin, Anna; Mcguinness, Shay; McVerry, Bryan; Montgomery, Stephanie K; Morpeth, Susan C; Mouncey, Paul R; Orr, Katrina; Parke, Rachael; Parker, Jane C; Patanwala, Asad E; Rowan, Kathryn M; Santos, Marlene S; Saunders, Christina T; Seymour, Christopher W; Shankar-Hari, Manu; Tong, Steven Y C; Turgeon, Alexis F; Turner, Anne M; Van de Veerdonk, Frank Leo; Zarychanski, Ryan; Green, Cameron; Berry, Scott; Marshall, John C; McArthur, Colin; Angus, Derek C; Webb, Steven A; REMAP-CAP Investigators
      Published 2021
      PURPOSE: To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). METHODS: Critically ill adults with COVID-19 were randomized to receive ...
      Article
    • Medications in Post-Acute and Long-Term Care: Challenges and Controversies 

      Sloane, P.D.; Brandt, N.J.; Cherubini, A.; Dharmarajan, T.S.; Dosa, D.; Hanlon, J.T.; Katz, P.; Koopmans, R.T.C.M.; Laird,R.D.; Petrovic, M.; Semla, T.P.; Tan, E.C.K.; Zimmerman, S.
      Published 2021
      Article
    • Microfluidic-assisted bacteriophage encapsulation into liposomes 

      Leung, Sharon SY; Morales, Sandra; Britton, Warwick; Kutter, Elizabeth; Chan, Hak-Kim
      Published 2018-07-10
      Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows reproducible mixing in miliseconds on the nanoliter scale. Here we investigated the feasibility of a microfluidic flow focusing ...
      Open Access
      Article
    • Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design 

      Khatib, Isra; Chow, Michael YT; Ruan, Juanfang; Cipolla, David; Chan, Hak-Kim
      Published 2021
      Spray drying was previously used to modify the physical form of the encapsulated ciprofloxacin drug to produce ciprofloxacin nanocrystals inside the liposomes (CNL). The purpose of the present study was to optimize CNL ...
      Open Access
      Article
    • Nanoparticles: the future for platinum drugs or a research red herring? 

      Wheate, Nial
      Published 2012-01-01
      Open Access
      Article
    • Nanoscale probing of liposome encapsulating drug nanocrystal using Atomic Force Microscopy-Infrared Spectroscopy 

      Khanal, Dipesh; Khatib, Isra; Ruan, Juanfang; Cipolla, David; Dayton, Francis; Blanchard, James; Chan, Hak-Kim; Chrzanowski, Wojciech
      Published 2020
      Use of liposomes encapsulating drug nanocrystals for the treatment of diseases like cancer and pulmonary infections is gaining attention. The potential therapeutic benefit of these engineered formulations relies on maintaining ...
      Open Access
      Article
    • A Narrative Review of COVID-19 Vaccines 

      Eroglu, B.; Nuwarda, R.F.; Ramzan, I.; Kayser, V.
      Published 2022
      The COVID-19 pandemic has shaken the world since early 2020 and its health, social, economic, and societal negative impacts at the global scale have been catastrophic. Since the early days of the pandemic, development of ...
      Other
    • Nebulisation effects on structural stability of bacteriophage PEV44 

      Astudillo, Ariel; Leung, Sharon Shui Yee; Kutter, Elizabeth; Morales, Sandra; Britton, Warwick J; Chan, Hak-Kim
      Published 2017-08-11
      Nebulization being used for inhaled phage therapy can cause phage titer losses which may be the result of mechanical damage to the phages. This study aimed to determine effects of nebulization on the structural stability ...
      Open Access
      Conference paper
    • Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19 

      Tai, Waiting; Chow, Michael Yee Tak; Chang, Rachel Yoon Kyung; Tang, Patricia; Gonda, Igor; MacArthur, Robert B; Chan, Hak-Kim; Kwok, Philip Chi Lip
      Published 2021
      The coronavirus disease 2019 (COVID-19) is an unprecedented pandemic that has severely impacted global public health and the economy. Hydroxychloroquine administered orally to COVID-19 patients was ineffective, but its ...
      Article