School of Medical Sciences: Recent submissions
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Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers.
Published 2016-05-01Peptide dendrimers are a novel class of macromolecules of emerging interest with the potential of delayed renal clearance due to their molecular size and enhanced activity due to the multivalency effect. In this work, an ...Open AccessArticle -
Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels.
Published 2012-03-29The opioid-related receptor, ORL1, is activated by the neuropeptide nociceptin/orphanin FQ (N/OFQ) and inhibits high-voltage-activated (HVA) calcium channel currents (I(Ca)) via a G-protein-coupled mechanism. Endocytosis ...Open AccessArticle -
Human chorionic gonadotropin increases β-cleavage of amyloid precursor protein in SH-SY5Y cells
Published 2013-08-01Elevated levels of amyloid-β (Aβ) peptides, the main component of amyloid plaques in Alzheimer's disease, are the result of excessive β- and γ-cleavage of the amyloid precursor protein (APP) and/or impaired Aβ clearance ...Open AccessArticle -
Multiple mechanisms of microglia: A gatekeeper's contribution to pain states
Published 2012-04-01Microglia are gatekeepers in the CNS for a wide range of pathological stimuli and they blow the whistle when things go wrong. Collectively, microglia form a CNS tissue alarm system (Kreutzberg's “sensor of pathology”), and ...Open AccessArticle -
Themed Section: Opioids New Pathways to Functional Selectivity
Published 2015-01-01"LINKED ARTICLES This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2"Open AccessArticle