School of Medical Sciences: Recent submissions
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Promethion Data
Published 2024-08-16This study examines the metabolic effects of different selenium compounds in mice using Promethion metabolic data. Forty mice were divided into five groups, each containing eight mice: Control, Sodium Selenite, ...Open AccessDataset -
Fluorinated Analogues of Desferrioxamine B from Precursor-Directed Biosynthesis Provide New Insight into the Capacity of DesBCD
Published 2018The siderophore desferrioxamine B (DFOB, 1) native to Streptomyces pilosus is biosynthesized by the DesABCD enzyme cluster. DesA-mediated decarboxylation of l-lysine gives 1,5-diaminopentane (DP) for processing by DesBCD. ...Open AccessArticle -
Engineering a cleavable disulfide bond into a natural product siderophore using precursor-directed biosynthesis
Published 2018An analogue of the bacterial siderophore desferrioxamine B (DFOB) containing a disulfide motif in the backbone was produced from Streptomyces pilosus cultures supplemented with cystamine. Cystamine competed against native ...Open AccessPreprint -
Siderophores and iron transport
Published 2023Siderophores are low-molecular-weight organic compounds produced by bacteria and fungi for Fe(III) supply. Bacteria and fungi biosynthesize siderophores in response to low iron, which are released into the local environment ...Book chapter -
Adding a diazo-transfer reagent to culture to generate secondary metabolite probes for click chemistry
Published 2022Converting discrete microbial metabolites into chemical probes for chemical biology and medicinal chemistry studies is typically preceded by lengthy purification and chemical derivatization processes. Standard practice ...Book chapter