Research Publications and Outputs: Recent submissions
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Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy.
Published 2009-01-01Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer. Methods: Medline was searched for 1) Cell models of ...Open AccessBook chapter -
A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome
Published 2008-02-19Transfected human ASK1 produces a 150kDa protein. However, we have detected endogenous ASK1 predominantly as 39kDa and 50kDa C-terminal and 75kDa and 110kDa N-terminal fragments in a panel of non-transfected cancer cell ...Open AccessArticle -
A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship
Published 2007-01-01We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for 1) cell models of acquired drug ...Open AccessArticle -
Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells
Published 2006-01-01Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ...Open AccessArticle -
Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review
Published 2007-01-01Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ...Open AccessArticle