Research Publications and Outputs: Recent submissions
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Regrowth resistance: low-level platinum resistance mediated by rapid recovery from platinum-induced cell-cycle arrest
Published 2009-01-01The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum drug resistance developed from H69 human small-cell lung cancer cells with eight 4-day treatments of 200 ng/ml cisplatin and 400 ng/ml oxaliplatin, ...Open AccessBook chapter -
Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy.
Published 2009-01-01Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer. Methods: Medline was searched for 1) Cell models of ...Open AccessBook chapter -
Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells
Published 2006-01-01Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ...Open AccessArticle -
Understanding cisplatin resistance using cellular models
Published 2007-01-01Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of ...Open AccessArticle -
A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship
Published 2007-01-01We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for 1) cell models of acquired drug ...Open AccessArticle