The Origins of SARS-CoV-2: A Critical Review
Type
ArticleAuthor/s
Holmes, Edward C.Goldstein, Stephen A.
Rasmussen, Angela L.
Robertson, David L.
Crits-Christoph, Alexander
Wertheim, Joel O.
Anthony, Simon J.
Barclay, Wendy S.
Boni, Maciej F.
Doherty, Peter C.
Farrar, Jeremy
Geoghegan, Jemma L.
Jiang, Xiaowei
Leibowitz, Julian L.
Neil, Stuart J.D.
Skern, Tim
Weiss, Susan R.
Worobey, Michael
Andersen, Kristian G.
Garry, Robert F.
Rambaut, Andrew
Abstract
Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.
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Date
2021Funding information
National Institutes of Health; Canada Foundation for Innovation; Australian Research Council
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