One-Pot Peptide Ligation–Desulfurization at Glutamate

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Open Access

Field	Value	Language
dc.contributor.author	Cergol, Katie M.
dc.contributor.author	Thompson, Robert E.
dc.contributor.author	Malins, Lara R.
dc.contributor.author	Turner, Peter
dc.contributor.author	Payne, Richard J.
dc.date.accessioned	2020-06-19
dc.date.available	2020-06-19
dc.date.issued	2013-12-02
dc.identifier.uri	https://pubs.acs.org/doi/abs/10.1021/ol403288n
dc.identifier.uri	https://hdl.handle.net/2123/22612
dc.description.abstract	An efficient methodology for ligation at glutamate (Glu) is described. A γ-thiol-Glu building block was accessed in only three steps from protected glutamic acid and could be incorporated at the N-terminus of peptides. The application of these peptides in one-pot ligation–desulfurization chemistry is demonstrated with a range of peptide thioesters, and the utility of this methodology is highlighted through the synthesis of the osteoporosis peptide drug teriparatide (Forteo).	en_AU
dc.language.iso	en_US	en_AU
dc.publisher	American Chemical Society	en_AU
dc.relation	ARC FT130100150	en_AU
dc.subject	Purification	en_AU
dc.subject	Peptides and proteins	en_AU
dc.subject	Monomers	en_AU
dc.subject	Ligation	en_AU
dc.subject	Desulfurization	en_AU
dc.title	One-Pot Peptide Ligation–Desulfurization at Glutamate	en_AU
dc.type	Article	en_AU
dc.subject.asrc	FoR::030599 - Organic Chemistry not elsewhere classified	en_AU
dc.subject.asrc	FoR::030499 - Medicinal and Biomolecular Chemistry not elsewhere classified	en_AU
dc.identifier.doi	10.1021/ol403288n
dc.type.pubtype	Post-print	en_AU