Objectives: To assess the clinical efficacy of renal artery denervation (RAD) in our center and to
compare the efficacy of two different radiofrequency (RF) systems.
Background: Several systems are available for RF renal denervation. Whether there is a difference
in clinical efficacy among various systems remains unknown.
Methods: Renal artery denervation was performed on 43 patients with resistant hypertension
using either the single electrode Symplicity Flex (n = 20) or the multi-electrode EnligHTN system
(n = 23). Median post-procedural follow-up was 32.93 months. The primary outcome was
post-procedural change in office blood pressure (BP) within 1 year (short-term follow-up). Secondary
outcomes were change in office BP between 1 and 4 years (long-term follow-up) and
the difference in office BP reduction between the two systems at each follow-up period.
Results: For the total cohort, mean baseline office BP (systolic/diastolic) was 174/94 mmHg. At
follow-up, mean changes in office BP from baseline were −19.70/−11.86 mmHg (P < 0.001) and
−21.90/−13.94 mmHg (P < 0.001) for short-term and long-term follow-up, respectively. The differences
in office BP reduction between Symplicity and EnligHTN groups were 8.96/1.23 mmHg
(P = 0.42 for systolic BP, P = 0.83 for diastolic BP) and 9.56/7.68 mmHg (P = 0.14 for systolic BP,
P = 0.07 for diastolic BP) for short-term and long-term follow-up, respectively.
Conclusions: In our cohort, there was a clinically significant office BP reduction after RAD,
which persisted up to 4 years. No significant difference in office BP reduction between the two
systems was found.