• Tetrapodal Anion Transporters 

      Gilchrist, Alexander M.; Chen, Lijun; Wu, Xin; Lewis, William; Howe, Ethan N.W.; Macreadie, Lauren K.; Gale, Philip A.
      Published 2020-01-01
      Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via ...
      Open Access
      Article
    • Development of a library of thiophene-based drug-like LEGO molecules: evaluation of their anion binding, transport properties and cytotoxicity 

      Vieira, Paulo; Miranda, Margarida Q.; Marques, Igor; Carvalho, Sílvia; Li-Jun, Chen; Howe, Ethan N.W.; Zhen, Carl; Leung, Claudia Y.; Spooner, Michael J.; Morgado, Bárbara; da Cruz e Silva, Odete A.B.; Moiteiro, Cristina; Gale, Philip A.; Félix, Vítor
      Published 2020-01-01
      The anion binding and transport properties of an extensive library of thiophene-based molecules are reported. Seventeen bis-urea positional isomers, with different binding conformations and lipophilicities, were synthetized ...
      Open Access
      Article
    • Design of Chiral Supramolecular Polymers Exhibiting a Negative Nonlinear Response 

      Chen, Xuan-Xuan; Lin, Xiao-Yan; Wu, Xin; Gale, Philip A.; Anslyn, Eric V.; Jiang, Yun-Bao
      Published 2019-01-01
      Many synthetic and supramolecular chiral polymeric systems are known to exhibit the “majority rules effect” (MRE), a positive nonlinear response in which a small enantiomeric excess (ee) of the chiral building blocks leads ...
      Open Access
      Article
    • Advances in Anion Receptor Chemistry 

      Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.
      Published 2020-01-01
      This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...
      Open Access
      Article
    • Selective anion transport mediated by strap-extended calixpyrroles 

      Clarke, Harriet J.; Wu, Xin; Light, Mark E.; Gale, Philip A.
      Published 2020-01-01
      Synthetic anion receptors that facilitate transmembrane chloride transport are of interest as potential therapeutic agents for cancer and cystic fibrosis. Transporters selective for chloride over protons are desired for ...
      Open Access
      Article