School of Chemistry: Recent submissions

    • Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display 

      Johansen-Leete, Jason; Ullrich, Sven; Fry, Sarah E.; Frkic, Rebecca; Bedding, Max J.; Aggarwal, Anupriya; Ashhurst, Anneliese S.; Ekanayake, Kasuni B.; Mahawaththa, Mithun C.; Sasi, Vishnu M.; Passioura, Toby; Larance, Mark; Otting, Gottfried; Turville, Stuart; Jackson, Colin J.; Nitsche, Christoph; Payne, Richard J.
      Published 2021
      Abstract Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19 pandemic. The main protease (M pro ) is essential for SARS-CoV-2 replication and is an attractive target for antiviral development. ...
      Preprint
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    • Discovery of Cyclic Peptide Ligands to the SARS-CoV_2 Spike Protein Using mRNA Display 

      Norman, Alexander; Franck, Charlotte; Christie, Mary; Hawkins, Paige M. E.; Patel, Karishma; Ashhurst, Anneliese S.; Aggarwal, Anupriya; Low, Jason K. K.; Siddiquee, Rezwan; Ashley, Caroline L.; Steain, Megan; Triccas, James A.; Turville, Stuart; Mackay, Joel P.; Passioura, Toby; Payne, Richard J.
      Published 2021
      The COVID-19 pandemic, caused by SARS-CoV-2, has led to substantial morbidity, mortality, and disruption globally. Cellular entry of SARS-CoV-2 is mediated by the viral spike protein, and affinity ligands to this surface ...
      Article
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    • Toward the identification of potential _-ketoamide covalent inhibitors for sars-cov-2 main protease: Fragment-based drug design and mm-pbsa calculations 

      El Hassab, M.A.; Fares, M.; Amin, M.K.A.-H.; Al-Rashood, S.T.; Alharbi, A.; Eskandrani, R.O.; Alkahtani, H.M.; Eldehna, W.M.
      Published 2021
      Since December 2019, the world has been facing the outbreak of the SARS-CoV-2 pandemic that has infected more than 149 million and killed 3.1 million people by 27 April 2021, according to WHO statistics. Safety measures ...
      Article
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    • Cylindrical Zwitterionic Particles via Interpolyelectrolyte Complexation on Molecular Polymer Brushes 

      Muellner, Markus; Nonappa; Mahon, Clare S.; Pelras, Theophile
      Published 2020
      The fabrication of macromolecular architectures with high aspect ratio and well‐defined internal and external morphologies remains a challenge. The combination of template chemistry and self‐assembly concepts to construct ...
      Open Access
      Article
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    • Element 5 – Boron 

      Rendina, Louis M.
      Published 2019
      2019 is the International Year of the Periodic Table of Chemical Elements (IYPT 2019), as declared by the United Nations General Assembly. This invited paper on boron is one in a series of essays about the chemical elements.
      Open Access
      Article
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