Browsing School of Chemistry by subject "0305 Organic Chemistry"
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Anion Recognition Using a Simple Cyclic Peptide
Published 2020The head-to-tail cyclic hexapeptide, [cyclo(Val-Thr)3], was found to bind to a range of anions in DMSO-d6 with higher affinity for tetrahedral oxo-anions than halides. 1H NMR spectroscopy indicated that anion binding results ...Open AccessArticle -
Cubanes in Medicinal Chemistry
Published 2019Cubane is a highly strained saturated hydrocarbon system that has historically been of interest in theoretical organic chemistry. More recently it has become a molecule of interest for biological applications due to its ...Open AccessArticle -
Cyclisation strategies for stabilising peptides with irregular conformations
Published 2021Cyclisation is a common synthetic strategy for enhancing the therapeutic potential of peptide-based molecules. While there are extensive studies on peptide cyclisation for reinforcing regular secondary structures such as ...Open AccessArticle -
Dual-functionalisation of fluorophores for the preparation of targeted and selective probes
Published 2020A key current challenge in biological research is the elucidation of the roles that chemicals and chemical reactions play in cellular function and dysfunction. Of the available cellular imaging techniques, ...Open AccessArticle -
Duale Funktionalisierung von Fluorophoren für die Konstruktion zielgerichteter und selektiver Fluoreszenz-Sensoren
Published 2020Eine Schlüsselfrage in der gegenwärtigen biologischen Forschung ist, welche Rolle gewisse Chemikalien und chemische Reaktionen im Zusammenhang mit dem regulären zellulären Betrieb, als auch mit zellulären Störungen spielen. ...Open AccessArticle -
E_File_10 - Free-Base Porphyrin 'Distal' Structure Potential Energy Surface Explorer.cdf
Published 2022-11-02Mathematica computable document format as described in Chapter 6 and Appendix F. Can be executed in Mathematica or using the free Wolfram PlayerOpen AccessInteractiveResource -
Element 5 – Boron
Published 20192019 is the International Year of the Periodic Table of Chemical Elements (IYPT 2019), as declared by the United Nations General Assembly. This invited paper on boron is one in a series of essays about the chemical elements.Open AccessArticle -
Elucidating the Roles of Fenton Reactants in Drug-Treated Cells using a Selective Rhodamine-Thiophenol Fluorogenic Sensor
Published 2021While Fenton chemistry has long been known to play a role in inducing cellular stress, there has been recent renewed interest in understanding its roles in health and disease. Here we describe a fluorogenic probe, RTFt1, ...Open AccessArticle -
Nicotinamide-appended fluorophores as fluorescent redox sensors
Published 2019Fluorescent sensors have proved invaluable in elucidating the regulation and dysregulation of redox processes in biology, but understanding of the breadth of biological redox reactions requires development of new sensors ...Open AccessArticle -
Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials
Published 2020The replacement of one chemical motif with another that is broadly similar is a common method in medicinal chemistry to modulate the physical and biological properties of a molecule (i.e., bioisosterism). In recent years, ...Open AccessArticle -
Strategies for organelle targeting of fluorescent probes
Published 2021Fluorescent tools have emerged as an important tool for studying the distinct chemical microenvironments of organelles, due to their high specificity and ability to be used in non-destructive, live cellular ...Open AccessArticle -
Studies of the labile lead pool using a rhodamine-based fluorescent probe
Published 2020Lead is a heavy metal which has long been known to have toxic effects on the body. However, much remains to be learnt about the labile lead pool and cellular uptake of lead. We report here RPb1 that undergoes a 100-fold ...Open AccessArticle -
Synthesis of nitro-aryl functionalised 4-amino-1,8-naphthalimides and their evaluation as fluorescent hypoxia sensors
Published 2020Fluorescent sensors are a vital research tool, enabling the study of intricate cellular processes in a sensitive manner. The design and synthesis of responsive and targeted probes is necessary to allow such processes to ...Open AccessArticle -
Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells
Published 2019Usnic acid is a secondary metabolite abundantly found in lichens, for which promising cytotoxic and antitumor potential has been shown. However, knowledge concerning activities of its derivatives is limited. Herein, a ...Open AccessArticle -
Synthesis, X-ray crystallographic analysis, DFT studies and biological evaluation of triazolopyrimidines and 2-anilinopyrimidines
Published 2022Inspired by the reported antiviral activity of pyrimidines and triazolopyrimidines, two series of 2-anilinopyrimidines (5a-e) and 1-aryl-[1,2,4]triazolo[4,3-a]pyrimidines (14a-k) were designed and synthesized as potential ...Open AccessArticle